School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China; Tianjin Key Laboratory for Control Theory & Applications in Complicated Industry Systems, School of Mechanical Engineering, Tianjin University of Technology, Tianjin, PR China.
Mater Sci Eng C Mater Biol Appl. 2016 Jun;63:450-61. doi: 10.1016/j.msec.2016.02.073. Epub 2016 Feb 27.
The biocompatibility, ultimate loading capacity and biodegradability of magnesium alloy make it an ideal candidate in biomedical fields. Fabrications of multilayered coatings carrying sodium alginate (ALG), chitosan (CHI) and mechano-growth factor (MGF) on fluoride-pretreated ZEK100 magnesium alloy have been obtained via layer by layer (LBL) to reduce the degradation rate of magnesium alloy in this study. The modified surfaces of ZEK100 substrates were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FTIR) and CARE EUT-1020 tester. Results reveal that multilayer-coated magnesium alloy can be successfully obtained with smooth surface morphology, and the mechanical properties of coated samples are almost the same as those of uncoated samples. However, the fatigue life of coated ZEK100 is slightly larger than that of uncoated samples after 1 day of immersion. By comparing the degradation of uncoated and multilayer-coated ZEK100 samples in vitro and in vivo, respectively, it is found that the degradation rate of ZEK100 samples can be inhibited by LBL modification on the surface of the sample; and the corrosion rate in vivo is lower than that in vitro, which help solve the rapid degradation problem of magnesium alloy. In terms of the visible symptom of tissues in the left femur medullary cavity and material responses on the surface, multilayer-coated ZEK100 magnesium alloy has a good biocompatibility. These results indicate that multilayer-coated ZEK100 may be a promising material for bone tissue repair.
镁合金的生物相容性、极限承载能力和生物降解性使其成为生物医学领域的理想候选材料。本研究通过层层自组装（LBL）技术在氟预处理 ZEK100 镁合金上制备了载有海藻酸钠（ALG）、壳聚糖（CHI）和机械生长因子（MGF）的多层涂层，以降低镁合金的降解速率。通过扫描电子显微镜（SEM）、原子力显微镜（AFM）、傅里叶变换红外光谱（FTIR）和 CARE EUT-1020 测试仪对 ZEK100 基底的改性表面进行了表征。结果表明，可成功获得表面形貌光滑的多层涂层镁合金，且涂层样品的力学性能几乎与未涂层样品相同。然而，经过 1 天浸泡后，涂层 ZEK100 的疲劳寿命略大于未涂层样品。通过比较体外和体内未涂层和多层涂层 ZEK100 样品的降解情况，发现 LBL 表面修饰可以抑制 ZEK100 样品的降解速率；体内的腐蚀速率低于体外，这有助于解决镁合金的快速降解问题。就左股骨髓腔组织的可见症状和表面的材料反应而言，多层涂层 ZEK100 镁合金具有良好的生物相容性。这些结果表明，多层涂层 ZEK100 可能是一种有前途的骨组织修复材料。
