Lehmann Leslie, El-Haddad Alaa, Barr Ronald D
Pediatric Stem Cell Transplant, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.
Department of Pediatric Oncology, 1 Fostat Street, Sayda Zainab, Cairo 11757, Egypt.
Hematol Oncol Clin North Am. 2016 Apr;30(2):417-32. doi: 10.1016/j.hoc.2015.11.008. Epub 2016 Jan 4.
Treatment of childhood hematologic malignancies requires multidisciplinary care and reliable infrastructural support; creating a this structure in resource-poor settings remains challenging. Ideally therapy would be tailored to each region and disease. The development of research initiatives is essential. Acute lymphoblastic leukemia (ALL) and lymphomas are common in low- and middle-income countries; treatment is often resource intense but likely cost effective. Outcomes currently are worse than those reported in high-income countries. Chronic myeloid leukemia can be treated effectively with imatinib. Strategies to decrease the burden of therapy and robust palliative care programs are essential for optimal treatment of all afflicted children.
儿童血液系统恶性肿瘤的治疗需要多学科护理和可靠的基础设施支持；在资源匮乏地区建立这样的体系仍然具有挑战性。理想情况下，治疗应根据每个地区和疾病进行定制。开展研究倡议至关重要。急性淋巴细胞白血病（ALL）和淋巴瘤在低收入和中等收入国家很常见；治疗通常资源密集但可能具有成本效益。目前的治疗结果比高收入国家报告的结果更差。慢性髓性白血病可用伊马替尼有效治疗。减轻治疗负担的策略和强有力的姑息治疗计划对于所有患病儿童的最佳治疗至关重要。
