Oxcarbazepine-induced liver injury after sensitization by valproic acid: a case report.
作者信息
Chait Mermelstein Alanna, Mermelstein Joseph, Adam Tarek, Brody Benjamin D, Dubin Marc J
机构信息
Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Mount Sinai Beth Israel/Icahn School of Medicine, New York, NY, USA.
出版信息
Bipolar Disord. 2016 May;18(3):307-309. doi: 10.1111/bdi.12381. Epub 2016 Apr 4.
OBJECTIVE
The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury.
METHODS
We report the case of a 46-year-old man with schizoaffective disorder who was cross-titrated from valproic acid to oxcarbazepine because of liver injury.
RESULTS
Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later.
CONCLUSIONS
Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.
Zotero 插件