Carey H V, Cooke H J
Department of Physiology, College of Medicine Ohio State University, Columbus 43210.
Life Sci. 1989;44(16):1083-8. doi: 10.1016/0024-3205(89)90335-4.
The influence of tonically active submucosal neurons on basal ion transport was studied using sheets of guinea pig ileum set up in flux chambers. Tetrodotoxin evoked an immediate and sustained decrease in short-circuit current that was sustained for 60 minutes compared with control tissues in which basal currents gradually decreased over time. Time-dependent changes in basal short-circuit currents in tissues treated with atropine were not significantly different from control tissues. The decrease in short-circuit current after tetrodotoxin resulted from a greater increase in net chloride absorption than sodium absorption. Changes in net sodium and chloride transport were due to an increase in the mucosal-to-serosal fluxes of these ions. The results suggest that tonic activity of submucosal neurons limits the absorptive capacity of the guinea pig ileum.
利用置于通量室中的豚鼠回肠片，研究了张力性活动的黏膜下神经元对基础离子转运的影响。与基础电流随时间逐渐降低的对照组织相比，河豚毒素引起短路电流立即且持续降低，并持续60分钟。用阿托品处理的组织中基础短路电流的时间依赖性变化与对照组织无显著差异。河豚毒素处理后短路电流的降低是由于氯化物净吸收的增加大于钠吸收的增加。钠和氯化物净转运的变化是由于这些离子从黏膜到浆膜通量的增加。结果表明，黏膜下神经元的紧张性活动限制了豚鼠回肠的吸收能力。
