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本文引用的文献

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Determination of the unmetabolised (18)F-FDG fraction by using an extension of simplified kinetic analysis method: clinical evaluation in paragangliomas.通过扩展简化动力学分析方法测定未代谢的（18）F-FDG 分数：副神经节瘤的临床评估
Med Biol Eng Comput. 2016 Jan;54(1):103-11. doi: 10.1007/s11517-015-1318-3. Epub 2015 Jun 5.
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A new PET/CT volumetric prognostic index for non-small cell lung cancer.一种用于非小细胞肺癌的新型PET/CT体积预后指数。
Lung Cancer. 2015 Jul;89(1):43-9. doi: 10.1016/j.lungcan.2015.03.023. Epub 2015 Apr 9.
3
FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a prospective multicentre study (RTEP2).放化疗期间的氟代脱氧葡萄糖正电子发射断层扫描可预测非小细胞肺癌患者1年时的预后：一项前瞻性多中心研究（RTEP2）
Eur J Nucl Med Mol Imaging. 2014 Jun;41(6):1057-65. doi: 10.1007/s00259-014-2687-9. Epub 2014 Feb 22.
4
Absence of a relationship between tumor ¹⁸F-fluorodeoxyglucose standardized uptake value and survival in patients treated with definitive radiotherapy for non-small-cell lung cancer.在接受非小细胞肺癌根治性放疗的患者中，肿瘤¹⁸F-氟脱氧葡萄糖标准化摄取值与生存率之间不存在相关性。
J Thorac Oncol. 2014 Mar;9(3):377-82. doi: 10.1097/JTO.0000000000000096.
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Prediction of survival by [18F]fluorodeoxyglucose positron emission tomography in patients with locally advanced non-small-cell lung cancer undergoing definitive chemoradiation therapy: results of the ACRIN 6668/RTOG 0235 trial.[18F]氟脱氧葡萄糖正电子发射断层扫描预测行根治性放化疗的局部晚期非小细胞肺癌患者的生存：ACRIN 6668/RTOG 0235 试验的结果。
J Clin Oncol. 2013 Oct 20;31(30):3823-30. doi: 10.1200/JCO.2012.47.5947. Epub 2013 Sep 16.
6
Response assessment using 18F-FDG PET early in the course of radiotherapy correlates with survival in advanced-stage non-small cell lung cancer.在放疗过程早期使用 18F-FDG PET 进行疗效评估与晚期非小细胞肺癌的生存相关。
J Nucl Med. 2012 Oct;53(10):1514-20. doi: 10.2967/jnumed.111.102566. Epub 2012 Aug 9.
7
PET-CT for radiotherapy treatment planning and response monitoring in solid tumors.正电子发射断层扫描（PET）-CT 在实体瘤放疗计划制定和反应监测中的应用。
Nat Rev Clin Oncol. 2011 Jan 25;8(4):233-42. doi: 10.1038/nrclinonc.2010.218.
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FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0.18F-FDG PET 和 PET/CT：欧洲核医学协会肿瘤 PET 成像操作指南：第 1.0 版。
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9
A pilot study of [18F]fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer.一项针对非小细胞肺癌患者在基于放射治疗期间及之后进行[18F]氟脱氧葡萄糖正电子发射断层扫描的初步研究。
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Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer.重复进行18F-FDG PET以监测III期非小细胞肺癌患者的新辅助化疗。
Lung Cancer. 2007 Feb;55(2):165-71. doi: 10.1016/j.lungcan.2006.09.028. Epub 2006 Nov 28.

非小细胞肺癌患者放疗期间早期预测临床反应的替代参数：概念验证研究

An alternative parameter for early forecasting clinical response in NSCLC patients during radiotherapy: proof of concept study.

作者信息

Padovani Laetitia, Baret Aurelie, Ciccolini Joseph, Taieb David, Bardia Farman, Teissonnier Laetitia, Muracciole Xavier, Barlesi Fabrice, Barbolosi Dominique

机构信息

1 SMARTc, INSERM, UMR 911 CRO2, Aix Marseille Université, Marseille, France.

2 Assistance Publique des Hôpitaux de Marseille, Radiotherapy Department, Marseille, France.

出版信息

Br J Radiol. 2016 Jun;89(1062):20160061. doi: 10.1259/bjr.20160061. Epub 2016 Apr 4.

DOI:10.1259/bjr.20160061
PMID:27043244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5258176/
Abstract

OBJECTIVE

Positron emission tomography with (18)F fludeoxyglucose integrated with CT ((18)F-FDG PET/CT) is a recommended imaging procedure in the evaluation of non-small-cell lung cancers (NSCLCs). Radiochemotherapy (RCT) is a mainstay for treatment of locally advanced NSCLC, for which overall survival still remains poor. Early evaluation of treatment response may help in decision-making to complete radiotherapy (RT) or to switch to other treatment modalities. The present study aimed to evaluate the performance of new metabolic parameters based on a simplified kinetic analysis on a single time point (SKA-S)-derived mathematical method, as compared with standardized uptake value (SUV) measurement during RT.

METHODS

Four patients treated with RT or RCT for NSCLC were evaluated using (18)F-FDG PET/CT during RT and after treatment completion. Whole-body (18)F-FDG PET/CT was performed followed by four additional list-mode acquisitions centered over the target lesion. Response was evaluated at four times (i.e. PET1-PET4) by calculating standard SUV values and T80%, the time taken to reach 80% of (18)F-FDG metabolized fraction using a SKA-S-derived mathematical method.

RESULTS

Data from SUV and T80% calculations were found to be controversial. T80% was found to be more predictive of clinical outcome.

CONCLUSION

Although results from this pilot study should be further confirmed in a large prospective study, the data suggest that T80% is a promising metabolic biomarker for assessing early response to RT.

ADVANCES IN KNOWLEDGE

In this proof of concept study, we show that T80% defined from a mathematic model taking into account the net influx rate constant and vascular volume could be consider as a promising biomarker as compared with the maximum SUV.

摘要

目的

(18)F氟脱氧葡萄糖正电子发射断层扫描与CT融合((18)F-FDG PET/CT)是评估非小细胞肺癌(NSCLCs)的推荐成像检查方法。放化疗(RCT)是局部晚期NSCLC的主要治疗手段，但其总生存期仍然较差。早期评估治疗反应可能有助于决定是否完成放疗(RT)或改用其他治疗方式。本研究旨在评估基于单时间点简化动力学分析(SKA-S)衍生数学方法的新代谢参数的性能，并与RT期间的标准化摄取值(SUV)测量进行比较。

方法

对4例接受RT或RCT治疗的NSCLC患者在RT期间和治疗完成后使用(18)F-FDG PET/CT进行评估。先进行全身(18)F-FDG PET/CT检查，然后在靶病变中心进行另外4次列表模式采集。通过计算标准SUV值和T80%（使用SKA-S衍生数学方法达到(18)F-FDG代谢分数80%所需的时间）在4个时间点（即PET1-PET4）评估反应。

结果

发现SUV和T80%计算的数据存在争议。发现T80%对临床结果的预测性更强。

结论

尽管这项初步研究的结果应在大型前瞻性研究中进一步证实，但数据表明T80%是评估RT早期反应的有前景的代谢生物标志物。

知识进展

在这项概念验证研究中，我们表明，与最大SUV相比，从考虑净流入速率常数和血容量的数学模型定义的T80%可被视为一种有前景的生物标志物。