Chee Jeremy, Ting Yohanes, Ong Yew Kwang, Chao Siew Shuen, Loh Kwok Seng, Lim Chwee Ming
Department of Otolaryngology - Head and Neck Surgery, National University Health System, Singapore.
Head Neck. 2016 Sep;38(9):1393-400. doi: 10.1002/hed.24451. Epub 2016 Apr 4.
The purpose of this study was to determine the prognostic value of relapse status (recurrent vs residual disease) in patients receiving surgical salvage for nasopharyngeal carcinoma (NPC).
Retrospective review was conducted on 52 patients who underwent salvage surgery for locoregional relapse of NPC. Univariate and multivariate analyses were used to investigate the prognostic value of relapse status.
Median follow-up duration was 44.4 months. Mean overall survival (OS) and disease-free survival (DFS) for patients with NPC with residual and recurrent disease after surgical salvage were 107.4 and 54.4 months, and 83.6 and 34.6 months, respectively (p < .001). This improved survival was demonstrated regardless whether the relapse was at the primary or nodal site. Multivariate analysis revealed that recurrent disease status and nodal disease relapse were independent poor prognostic factors for survival in patients receiving salvage surgery for NPC.
In patients undergoing surgical salvage for NPC relapse, residual disease carries a better prognosis than recurrent disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1393-1400, 2016.
本研究旨在确定接受手术挽救治疗的鼻咽癌（NPC）患者中复发状态（复发与残留疾病）的预后价值。
对52例行NPC局部区域复发挽救性手术的患者进行回顾性分析。采用单因素和多因素分析来研究复发状态的预后价值。
中位随访时间为44.4个月。手术挽救后残留和复发疾病的NPC患者的平均总生存期（OS）和无病生存期（DFS）分别为107.4和54.4个月，以及83.6和34.6个月（p <.001）。无论复发是在原发部位还是淋巴结部位，均显示出生存改善。多因素分析显示，复发疾病状态和淋巴结疾病复发是接受NPC挽救性手术患者生存的独立不良预后因素。
在接受NPC复发手术挽救的患者中，残留疾病的预后优于复发疾病。©2016威利期刊公司。头颈外科38: 1393 - 1400, 2016。
