Veljković S, Jovanović-Mićić D, Japundzić N, Samardzić R, Beleslin D B
Department of Pharmacology, Medical Faculty, Belgrade, Yugoslavia.
Metab Brain Dis. 1989 Mar;4(1):61-5. doi: 10.1007/BF00999495.
The intracerebroventricular administration of angiotensin II in pentobarbital-anesthetized cats produced dose-dependent increases in the arterial blood pressure without significant changes in the heart rate. The ablation of the area postrema significantly reduced, but did not abolish, the pressor effect of angiotensin injected into the cerebral ventricles. It follows, then, that the central pressor effect of angiotensin is dependent on the integrity of the area postrema and that this central site, at least in part, contributes to the pressor action of endogenous angiotensin.
在戊巴比妥麻醉的猫中，脑室内注射血管紧张素II可使动脉血压呈剂量依赖性升高，而心率无显著变化。损毁最后区可显著降低但并未消除脑室内注射血管紧张素的升压作用。因此可以推断，血管紧张素的中枢升压作用依赖于最后区的完整性，并且这个中枢部位至少部分地促成了内源性血管紧张素的升压作用。
