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水中基于吡唑的吡啶并[2,3 - d]嘧啶二酮的新型高效五组分合成：三重绿色合成

A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis.

作者信息

Heravi Majid M, Daraie Mansoureh

机构信息

Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran.

出版信息

Molecules. 2016 Apr 1;21(4):441. doi: 10.3390/molecules21040441.

DOI:10.3390/molecules21040441
PMID:27043522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6274230/
Abstract

A novel one pot synthesis of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported.

摘要

报道了一种通过五组分反应一锅法合成吡唑并[4',3':5,6]吡啶并[2,3-d]嘧啶二酮的方法，该反应涉及水合肼、乙酰乙酸乙酯、1,3-二甲基巴比妥酸、合适的芳醛和乙酸铵，在水相中通过非均相和均相催化进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/9942c9187c6f/molecules-21-00441-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/576e9b29e906/molecules-21-00441-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/89842a96ec6f/molecules-21-00441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/f63749bf0695/molecules-21-00441-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/00e74002b780/molecules-21-00441-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/9942c9187c6f/molecules-21-00441-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/576e9b29e906/molecules-21-00441-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/89842a96ec6f/molecules-21-00441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/f63749bf0695/molecules-21-00441-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/00e74002b780/molecules-21-00441-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c550/6274230/9942c9187c6f/molecules-21-00441-sch004.jpg

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