口咽鳞状细胞癌患者肾功能受损与预后不良的相关性

Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma.

作者信息

Homma Akihiro, Hayashi Ryuichi, Kawabata Kazuyoshi, Fujii Takashi, Iwae Shigemichi, Hasegawa Yasuhisa, Nibu Kenichi, Kato Takakuni, Shiga Kiyoto, Matsuura Kazuto, Monden Nobuya, Fujii Masato

机构信息

Department of Otolaryngology - Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Head and Neck Surgery Division, National Cancer Center Hospital East, Kashiwa, Japan.

出版信息

Head Neck. 2016 Oct;38(10):1495-500. doi: 10.1002/hed.24467. Epub 2016 Apr 4.

DOI:10.1002/hed.24467

PMID:27044005

Abstract

BACKGROUND

Renal function influences decisions regarding treatment for patients with oropharyngeal squamous cell carcinoma (SCC). However, the importance of renal function in oropharyngeal SCC has not yet been reported.

METHODS

Four hundred sixty patients with oropharyngeal SCC treated with curative intent between April 2005 and March 2007 in 12 institutions in Japan were analyzed retrospectively.

RESULTS

Four hundred three patients (87.6%) showed a creatinine clearance (CrCl) ≥50 mL/min and 57 (12.4%) with a CrCl <50 mL/min. Age was associated with worse overall survival (OS), whereas stage IVB, radiotherapy (RT), and CrCl <50 were associated with worse OS on univariate analyses. Surgery and hypertension were associated with better OS on univariate analyses. On multivariate analysis, age, stage, hypertension, and CrCl were also found to be significantly associated with OS.

CONCLUSION

Based on this retrospective study, impaired renal function is an independent predictor of increased risk of death in patients with oropharyngeal SCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1500, 2016.

摘要

背景

肾功能会影响口咽鳞状细胞癌（SCC）患者的治疗决策。然而，肾功能在口咽鳞状细胞癌中的重要性尚未见报道。

方法

对2005年4月至2007年3月期间在日本12家机构接受根治性治疗的460例口咽鳞状细胞癌患者进行回顾性分析。

结果

403例患者（87.6%）的肌酐清除率（CrCl）≥50 mL/分钟，57例（12.4%）的CrCl<50 mL/分钟。年龄与总生存期（OS）较差相关，而在单因素分析中，IVB期、放疗（RT）和CrCl<50与较差的OS相关。在单因素分析中，手术和高血压与较好的OS相关。在多因素分析中，年龄、分期、高血压和CrCl也被发现与OS显著相关。