Departamento de Cirurgia de Cabeca e Pescoco e Otorrinolaringologia, A.C. Camargo Cancer Center, Sao Paulo, SP, BR.
Grupo de Epidemiologia e Estatistica em Cancer, Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, Sao Paulo, SP, BR.
Clinics (Sao Paulo). 2020 Apr 6;75:e1507. doi: 10.6061/clinics/2020/e1507. eCollection 2020.
We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends.
The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models.
Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year.
Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.
本研究旨在评估口腔和口咽鳞状细胞癌（SCC）患者的总生存（OS）和条件生存（CS），并确定其生存趋势。
本研究纳入了 2001 年至 2012 年在 A.C. Camargo 癌症中心接受口腔或口咽 SCC 治疗的所有连续患者。数据来自医院癌症登记处。采用 Kaplan-Meier 法分析 OS 和 CS，并用 Cox 预测模型评估生存概率。
分析了 2001-2006 年和 2007-2012 年获得的 505 例口腔 SCC 和 380 例口咽 SCC 患者的数据。大多数口腔 SCC（59%）和口咽 SCC（90%）患者为 III-IV 期 SCC。口腔 SCC 患者的 5 年 OS 为 51.7%，两个时期之间无显著差异。2007-2012 年 CS 率在第一年为 65%，第五年为 86%。口咽 SCC 的 5 年 OS 率在第一时期为 45.0%。2007 年至 2012 年，OS 率从 49.1%增加，死亡风险降低（HR=0.69；0.52-09.2）。2007-2012 年 CS 估计值在第一年为 59%，第五年为 75%。
两个时期的口腔 SCC 生存保持稳定，但口咽 SCC 的生存显著增加，这可能是由于患者对放疗的反应（如强度调制放疗）和更准确的诊断成像方法的改善。
