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[成年患者原发性甲状腺功能减退症的治疗]

[Treatment of primary hypothyroidism in adult patients].

作者信息

Salmela Pasi, Metso Saara, Moilanen Leena, Niskanen Leo, Nuutila Pirjo, Schalin-Jäntti Camilla

出版信息

Duodecim. 2016;132(1):33-42.

PMID:27044179
Abstract

The diagnosis of hypothyroidism is based on the findings of an increased serum TSH (above the reference range) and decreased serum free T4 (below the reference range) concentration. Treatment of subclinical hypothyroidism is indicated if serum THS is above 10 mU/l. For less severe forms of subclinical hypothyroidism, the treatment should be individually tailored. The treatment of choice is synthetic human levothyroxine. The goals for treatment are amelioration of symptoms and normalization of TSH and free T4 concentrations.

摘要

甲状腺功能减退症的诊断基于血清促甲状腺激素(TSH)升高(高于参考范围)和血清游离甲状腺素(T4)浓度降低(低于参考范围)的检查结果。如果血清TSH高于10 mU/l,则需对亚临床甲状腺功能减退症进行治疗。对于不太严重的亚临床甲状腺功能减退症形式,治疗应个体化定制。治疗的首选药物是合成人左甲状腺素。治疗目标是缓解症状以及使TSH和游离T4浓度恢复正常。

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1
[Treatment of primary hypothyroidism in adult patients].[成年患者原发性甲状腺功能减退症的治疗]
Duodecim. 2016;132(1):33-42.
2
Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine.与原发性甲状腺疾病相比,TSH 缺乏症的甲状腺功能减退症的诊断和治疗:垂体患者接受左甲状腺素替代治疗不足的风险更高。
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Seasonal variation of serum thyrotropin concentration and thyrotropin response to thyrotropin-releasing hormone in patients with primary hypothyroidism on constant replacement dosage of thyroxine.接受恒定剂量甲状腺素替代治疗的原发性甲状腺功能减退症患者血清促甲状腺激素浓度的季节性变化以及促甲状腺激素对促甲状腺激素释放激素的反应。
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Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism.在中枢性甲状腺功能减退症中,甲状腺激素替代治疗对促甲状腺激素的抑制作用与甲状腺素水平正常化相关。
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Changes in serum triiodothyronine, thyroxine, and thyrotropin during treatment with thyroxine in severe primary hypothyroidism.重度原发性甲状腺功能减退症患者在接受甲状腺素治疗期间血清三碘甲状腺原氨酸、甲状腺素和促甲状腺激素的变化。
J Clin Endocrinol Metab. 1976 Jul;43(1):10-7. doi: 10.1210/jcem-43-1-10.
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[Subclinical hypothyroidism].[亚临床甲状腺功能减退症]
Rev Med Brux. 2004 Jun;25(3):141-7.
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Hypothyroidism in adults. Levothyroxine if warranted by clinical and laboratory findings, not for simple TSH elevation.成人甲状腺功能减退症。若临床和实验室检查结果表明有必要,则使用左甲状腺素,单纯促甲状腺激素升高者不适用。
Prescrire Int. 2015 Oct;24(164):241-4, 246.
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Clinical significance of TSH circadian variability in patients with hypothyroidism.甲状腺功能减退症患者 TSH 昼夜节律变化的临床意义。
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Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism.左甲状腺素联合三碘甲状腺原氨酸(生物可利用摩尔比为14:1)进行替代治疗,在改善甲状腺功能减退患者的健康状况和认知表现方面并不优于单独使用甲状腺素。
Clin Endocrinol (Oxf). 2004 Jun;60(6):750-7. doi: 10.1111/j.1365-2265.2004.02050.x.