[先于银屑病出现的银屑病关节炎的临床和实验室特征]
[Clinical and laboratory features of psoriatic arthritis which antedates psoriasis].
作者信息
Li Yuhui, Yao Haihong, Jia Yuan, Jin Fuan, Zhang Chunfang, Zhang Jian, Zhang Xuewu, Li Zhanguo
机构信息
Department of Rheumatology and Immunity, People's Hospital, Peking University, Beijing 100044, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2016 Mar 22;96(11):883-5. doi: 10.3760/cma.j.issn.0376-2491.2016.11.012.
OBJECTIVE
To analyze the clinical and laboratory features of psoriatic arthritis (PsA) which antedates psoriasis.
METHODS
The clinical and laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulins, antibodies of 113 patients with PsA were analyzed retrospectively and compared by order of the occurrence of arthritis.
RESULTS
The occurrence of psoriatic arthritis which antedates psoriasis was 22.1% in the study. The onset of arthritis was 2 months to 25 years earlier than psoriasis. Arthritis of distal interphalangeal (DIP) joints was frequently involved in this group and arthritis of hip joints was rare. Positive HLA-B27 and higher level of platelet (PLT), ESR, CRP, and IgA were common in patients with psoriatic arthritis which antedates psoriasis.
CONCLUSION
Arthritis of DIP joints and elevated inflammatory markers are frequently involved in patients with psoriatic arthritis which antedates psoriasis, and somewhat they are associated with disease activity.
目的
分析先于银屑病出现的银屑病关节炎（PsA）的临床和实验室特征。
方法
回顾性分析113例PsA患者的临床和实验室数据，包括红细胞沉降率（ESR）、C反应蛋白（CRP）、免疫球蛋白等，并按关节炎出现顺序进行比较。
结果
本研究中先于银屑病出现的银屑病关节炎发生率为22.1%。关节炎发病比银屑病早2个月至25年。该组中远端指间关节（DIP）关节炎受累常见，髋关节关节炎罕见。先于银屑病出现的银屑病关节炎患者中，HLA - B27阳性以及血小板（PLT）、ESR、CRP和IgA水平较高较为常见。
结论
先于银屑病出现的银屑病关节炎患者常出现DIP关节关节炎和炎症标志物升高，且在一定程度上与疾病活动相关。
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