Aucella Filippo, Santoro Antonio
Department of Nephrology and Dialysis , Scientific Institute "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo , Italy.
Department of Nephrology, Dialysis and Hypertension , S.Orsola-Malpighi Hospital , Bologna , Italy.
NDT Plus. 2010 May;3(Suppl 1):i1-i2. doi: 10.1093/ndtplus/sfq030.
The choice of dialyzer may affect the dialysis process more than any other single component of the dialysis system. Over the past five decades, membranes used for the treatment of chronic kidney disease have continuously evolved, and the use of classical non-modified cellulose membranes has declined in favor of cellulose-based membranes in which the basic structure has been modified to improve the biocompatibility profile of the material as well as membranes based on synthetic polymers. Dialysis membranes with the best biological properties should be biocompatible, exclude impurities in the dialysate and have a large pore size. A high adsorptive capacity, a main feature of the polymethylmetacrylate (PMMA) membranes, is high helpful and may both increase the total amount of solutes removed and removes different kinds of solutes. Moreover, PMMA dialyzer membrane has a good chance to obtain an optimal rather than an adequate dialysis in the field of biocompatibility, immune regulation and inflammation.
透析器的选择对透析过程的影响可能超过透析系统的任何其他单一组件。在过去的五十年里，用于治疗慢性肾病的膜不断发展，传统未改性纤维素膜的使用减少，转而青睐纤维素基膜，其中基本结构已被改性以改善材料的生物相容性，以及基于合成聚合物的膜。具有最佳生物学特性的透析膜应具有生物相容性，排除透析液中的杂质且孔径较大。高吸附能力是聚甲基丙烯酸甲酯（PMMA）膜的一个主要特性，非常有帮助，它既可以增加溶质清除总量，又能清除不同种类的溶质。此外，在生物相容性、免疫调节和炎症领域，PMMA透析器膜有机会实现最佳透析而非仅仅是充分透析。
