Bartov I
Department of Poultry Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel.
Poult Sci. 1989 Jan;68(1):145-52. doi: 10.3382/ps.0680145.
Effects of dietary fat, protein, and methionine levels and the type of dietary grain in nicarbazin-containing diets on the growth response of broiler chicks were evaluated in five experiments in a factorial design. Nicarbazin at levels ranging from 100 to 200 mg/kg significantly (P less than .05) depressed weight gain and feed efficiency. Feed intake was significantly reduced only when nicarbazin was used at levels of 150 and 200 mg/kg. The latter concentration also significantly decreased water intake and water:feed ratio. Nicarbazin, at a level of 150 mg/kg, did not affect dietary metabolizable energy content or the retention of nitrogen and dry matter. A higher level of soybean oil (3.5 vs. .5 or 1.0%) did not counteract the growth-depressing effects of 100, 150, and 200 mg nicarbazin/kg. The growth-depressing effect of the highest dose also was not affected by increasing the protein level from 18.2 to 20.4%. Neither type of dietary grains (corn vs. sorghum) nor supplemental methionine level affected the toxicity of 125 mg nicarbazin/kg. Water intake and water:feed ratio were significantly increased due to elevation of dietary protein and fat levels. It was concluded that the severity of the growth-depressing effect of nicarbazin on chicks was not dependent on the levels of dietary unsaturated fat, protein, and methionine.
在五项析因设计实验中，评估了含尼卡巴嗪日粮中的膳食脂肪、蛋白质和蛋氨酸水平以及谷物类型对肉鸡生长反应的影响。尼卡巴嗪含量在100至200毫克/千克之间时显著（P小于0.05）降低了体重增加和饲料效率。仅当尼卡巴嗪用量为150和200毫克/千克时，采食量才显著降低。后一浓度也显著降低了饮水量和水料比。150毫克/千克水平的尼卡巴嗪不影响日粮代谢能含量或氮和干物质的保留。较高水平的大豆油（3.5%对0.5%或1.0%）不能抵消100、150和200毫克/千克尼卡巴嗪的生长抑制作用。最高剂量的生长抑制作用也不受蛋白质水平从18.2%提高到20.4%的影响。日粮谷物类型（玉米对高粱）和补充蛋氨酸水平均不影响125毫克/千克尼卡巴嗪的毒性。由于日粮蛋白质和脂肪水平的提高，饮水量和水料比显著增加。得出的结论是，尼卡巴嗪对雏鸡生长抑制作用的严重程度不取决于日粮不饱和脂肪、蛋白质和蛋氨酸的水平。
