Haematology Unit - Haemophilia Centre of Northern Greece, 2nd Propedeutic Department of Internal Medicine, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Haematology Unit - Haemophilia Centre of Northern Greece, 2nd Propedeutic Department of Internal Medicine, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Thromb Res. 2016 Apr;140:14-21. doi: 10.1016/j.thromres.2016.02.001. Epub 2016 Feb 2.
Advances in hemophilia care have led to increased life expectancy and new challenges in the management of the aging hemophilia population, including cardiovascular risk. Despite the deep knowledge into cardiovascular disease in terms of pathophysiology, risk prediction, prevention, early detection and management gained over the last decades, studies in hemophiliacs are scarce and mainly descriptive. As a growing amount of evidence points towards a similar or increased prevalence of traditional cardiovascular risk factors in hemophilia compared to the general population, the role of non-traditional, disease-related and treatment-related cardiovascular risk factors remains under investigation. Better understanding of cardiovascular risk in hemophilia is mandatory for proper cardiovascular risk prevention and management. Therefore, this review aims to summarize current knowledge on cardiovascular risk in hemophilia patients focusing on a) cardiovascular risk factors (traditional, non-traditional, disease-related and treatment-related), b) cardiovascular morbidity and mortality and c) cardiovascular prevention and management.
血友病治疗的进步使得患者的预期寿命延长，老龄化血友病患者的管理也面临新的挑战，包括心血管风险。尽管过去几十年在心血管疾病的病理生理学、风险预测、预防、早期发现和管理方面已经有了深入的了解，但在血友病患者中的研究仍然很少，而且主要是描述性的。随着越来越多的证据表明，与普通人群相比，血友病患者中传统心血管危险因素的患病率相似或更高，因此非传统、与疾病相关和与治疗相关的心血管危险因素的作用仍在研究中。更好地了解血友病患者的心血管风险对于进行适当的心血管风险预防和管理是必要的。因此，本综述旨在总结目前关于血友病患者心血管风险的知识，重点关注：a）心血管危险因素（传统、非传统、与疾病相关和与治疗相关）；b）心血管发病率和死亡率；c）心血管预防和管理。
