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P-glycoprotein transporter in drug development.

作者信息

Prachayasittikul Veda, Prachayasittikul Virapong

机构信息

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Dental Hospital Mahidol University Faculty of Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

出版信息

EXCLI J. 2016 Feb 12;15:113-8. doi: 10.17179/excli2015-768. eCollection 2016.

DOI:10.17179/excli2015-768
PMID:27047321
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4817426/
Abstract
摘要

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本文引用的文献

1
Classification of P-glycoprotein-interacting compounds using machine learning methods.使用机器学习方法对P-糖蛋白相互作用化合物进行分类
EXCLI J. 2015 Aug 19;14:958-70. doi: 10.17179/excli2015-374. eCollection 2015.
2
Exploring the Chemical Space of P-Glycoprotein Interacting Compounds.探索P-糖蛋白相互作用化合物的化学空间
Mini Rev Med Chem. 2017;17(14):1332-1345. doi: 10.2174/1389557516666160121120344.
3
Computer-Aided Drug Design of Bioactive Natural Products.生物活性天然产物的计算机辅助药物设计
Curr Top Med Chem. 2015;15(18):1780-800. doi: 10.2174/1568026615666150506151101.
4
Docking applied to the prediction of the affinity of compounds to P-glycoprotein.对接技术在预测化合物与P-糖蛋白亲和力中的应用。
Biomed Res Int. 2014;2014:358425. doi: 10.1155/2014/358425. Epub 2014 May 27.
5
Evaluation of oxidative stress in placenta of fetal cardiac dysfunction rat model and antioxidant defenses of maternal vitamin C supplementation with the impacts on P-glycoprotein.胎儿心脏功能障碍大鼠模型胎盘氧化应激评估及母体补充维生素C的抗氧化防御作用对P-糖蛋白的影响
J Obstet Gynaecol Res. 2014 Jun;40(6):1632-42. doi: 10.1111/jog.12389.
6
The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein--a well-known, yet poorly understood drug transporter.分子对接技术解析与P-糖蛋白相关争议和挑战的能力——P-糖蛋白是一种广为人知但却了解甚少的药物转运蛋白。
Invest New Drugs. 2014 Aug;32(4):618-25. doi: 10.1007/s10637-014-0098-1. Epub 2014 Apr 22.
7
Expression of HIF-1α and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone.马桑内酯点燃的难治性内侧颞叶癫痫患者及药物抵抗性颞叶癫痫大鼠模型中HIF-1α和MDR1/P-糖蛋白的表达
Neurol Sci. 2014 Aug;35(8):1203-8. doi: 10.1007/s10072-014-1681-0. Epub 2014 Mar 4.
8
ADMET evaluation in drug discovery. 13. Development of in silico prediction models for P-glycoprotein substrates.药物发现中的ADMET评估。13. P-糖蛋白底物的计算机预测模型的开发。
Mol Pharm. 2014 Mar 3;11(3):716-26. doi: 10.1021/mp400450m. Epub 2014 Feb 18.
9
A genetic algorithm- back propagation artificial neural network model to quantify the affinity of flavonoids toward P-glycoprotein.一种用于量化黄酮类化合物与P-糖蛋白亲和力的遗传算法-反向传播人工神经网络模型。
Comb Chem High Throughput Screen. 2014 Feb;17(2):162-72. doi: 10.2174/1386207311301010002.
10
Ligand and structure-based classification models for prediction of P-glycoprotein inhibitors.基于配体和结构的 P-糖蛋白抑制剂预测分类模型。
J Chem Inf Model. 2014 Jan 27;54(1):218-29. doi: 10.1021/ci400289j. Epub 2014 Jan 9.