他汀类药物在造血干细胞移植中的临床应用：旧药新视野
Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons.
作者信息
Mohammadi Mehdi, Vaezi Mohammad, Mirrahimi Bahador, Hadjibabaie Molouk
机构信息
Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Hematol Oncol Stem Cell Res. 2016 Jan 1;10(1):42-50.
Hydroxymethylglutaryl Co-enzyme A reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. These drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. Soon after their introduction, benefits other than their primary actions were discovered. Along with these pleiotropic properties, a series of mainly favorable effects has been proposed in patients intended to undergo hematopoietic stem cell transplantation. These actions address some complications encountered by this special population such as graft-versus-host disease, efficacy of chemotherapy, infections, etc. This review presents the current evidence surrounding these issues.
羟甲基戊二酰辅酶A还原酶抑制剂，也被称为他汀类药物，是一类抗高脂血症药物。这些药物已被广泛用于降低心血管疾病的发病率和死亡率。在它们被引入后不久，就发现了其主要作用之外的益处。伴随着这些多效性特性，在拟进行造血干细胞移植的患者中提出了一系列主要是有益的作用。这些作用解决了这一特殊人群所遇到的一些并发症，如移植物抗宿主病、化疗疗效、感染等。本综述介绍了围绕这些问题的当前证据。
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