Department of Medical Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
Clin Transl Oncol. 2014 Jan;16(1):85-90. doi: 10.1007/s12094-013-1046-9. Epub 2013 Apr 30.
Statins have beneficial effects in patients after myocardial infarction and at least part of the benefit results from mobilization of marrow endothelial progenitors to repopulate damaged myocardial tissues. This study examines if statins may have the same effect in mobilizing marrow progenitors to be harvested and subsequently used in high-dose chemotherapy with progenitor cell rescue in multiple myeloma.
From 2006 to 2012, 86 patients with multiple myeloma were mobilized with the use of G-CSF and were retrospectively analyzed. Patients with other malignancies or mobilized with the use of chemotherapy or with plerixafor were excluded.
The median age of the patients was 60 years. 72 patients had received one line of chemotherapy and 14 patients two or more lines of chemotherapy. Twenty patients were taking statins at the time of the harvest while 66 patients were not. In the group of patients taking statins the success rate of first leukapheresis (obtaining the target number of 4 × 10(6) CD34+ cells/kg) was 85 % while in the group not taking statins this rate was 63.6 %. Despite the comparatively small number of patients this difference approached statistical significance (χ (2) = 0.07).
This retrospective analysis of 86 patients shows for the first time a possible benefit of statins for peripheral blood progenitor cells mobilization in patients with multiple myeloma. Larger studies would be required to clarify the issue. If their effectiveness is confirmed, statins could be a safe and cheaper addition to chemotherapy and plerixafor for peripheral hematopoietic stem cell mobilization.
他汀类药物对心肌梗死后患者有有益的影响，其部分益处源自动员骨髓内皮祖细胞来修复受损的心肌组织。本研究旨在探讨他汀类药物是否具有相同的作用，即动员骨髓祖细胞进行采集，并随后在高剂量化疗中与祖细胞挽救联合用于多发性骨髓瘤。
2006 年至 2012 年，我们对 86 例多发性骨髓瘤患者进行了动员，采用 G-CSF，并进行了回顾性分析。排除了患有其他恶性肿瘤或接受化疗动员或使用培非格司亭动员的患者。
患者的中位年龄为 60 岁。72 例患者接受过一线化疗，14 例患者接受过二线或以上的化疗。20 例患者在采集时正在服用他汀类药物，66 例患者未服用。在服用他汀类药物的患者组中，首次白细胞分离术（获得目标数量为 4×10(6) CD34+细胞/kg）的成功率为 85%，而未服用他汀类药物的患者组这一比例为 63.6%。尽管患者数量相对较少，但这一差异接近统计学意义（χ(2) = 0.07）。
这项对 86 例患者的回顾性分析首次表明，他汀类药物可能对多发性骨髓瘤患者的外周血祖细胞动员有益。需要更大规模的研究来阐明这个问题。如果其有效性得到证实，他汀类药物可能成为化疗和培非格司亭动员外周造血干细胞的一种安全且更经济的选择。
