对合并神经受累的系统性红斑狼疮进行免疫抑制治疗后，假性升高的肿瘤标志物水平降低。
Diminution of falsely elevated tumour markers following immunosuppression for systemic lupus erythematosus with neurological involvement.
作者信息
Bevan Jonathan, Richardson Michael
机构信息
Department of Rheumatology, Jersey General Hospital, Saint Helier, Jersey.
出版信息
BMJ Case Rep. 2016 Apr 5;2016:bcr2016214549. doi: 10.1136/bcr-2016-214549.
Abstract
We describe the case of a patient with a long history of undifferentiated connective tissue disease who developed headache, ataxia and orofacial dyskinesia attributed to a diagnosis of systemic lupus erythematosus (SLE). Gross elevation of the concentration of several plasma tumour markers (CEA, CA-125, CA19-9, CA15-3) was detected in the absence of malignancy. These markers fell significantly within a month of starting immunosuppressive therapy alongside clinical improvement. Caution should be taken in the interpretation of plasma tumour markers in patients with connective tissue disease.
摘要
我们描述了一例有长期未分化结缔组织病病史的患者，该患者出现头痛、共济失调和口面部运动障碍，诊断为系统性红斑狼疮（SLE）。在无恶性肿瘤的情况下，检测到几种血浆肿瘤标志物（癌胚抗原、CA-125、CA19-9、CA15-3）浓度显著升高。在开始免疫抑制治疗并伴有临床改善的一个月内，这些标志物显著下降。对于结缔组织病患者血浆肿瘤标志物的解读应谨慎。
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