Bevan Jonathan, Richardson Michael
Department of Rheumatology, Jersey General Hospital, Saint Helier, Jersey.
BMJ Case Rep. 2016 Apr 5;2016:bcr2016214549. doi: 10.1136/bcr-2016-214549.
We describe the case of a patient with a long history of undifferentiated connective tissue disease who developed headache, ataxia and orofacial dyskinesia attributed to a diagnosis of systemic lupus erythematosus (SLE). Gross elevation of the concentration of several plasma tumour markers (CEA, CA-125, CA19-9, CA15-3) was detected in the absence of malignancy. These markers fell significantly within a month of starting immunosuppressive therapy alongside clinical improvement. Caution should be taken in the interpretation of plasma tumour markers in patients with connective tissue disease.
我们描述了一例有长期未分化结缔组织病病史的患者，该患者出现头痛、共济失调和口面部运动障碍，诊断为系统性红斑狼疮（SLE）。在无恶性肿瘤的情况下，检测到几种血浆肿瘤标志物（癌胚抗原、CA-125、CA19-9、CA15-3）浓度显著升高。在开始免疫抑制治疗并伴有临床改善的一个月内，这些标志物显著下降。对于结缔组织病患者血浆肿瘤标志物的解读应谨慎。
