West H J
Department of Veterinary Clinical Science, University of Liverpool, South Wirral.
Res Vet Sci. 1989 Mar;46(2):231-7.
The possibility that alterations in liver function may occur during late pregnancy as well as after calving has been investigated in healthy dairy cows and the results compared with those from non-pregnant non-lactating cows. There were significant alterations in plasma total bilirubin, glucose, total ketone body and urea concentrations, in bromsulphthalein clearance and in plasma aspartate aminotransferase and creatine kinase activities in periparturient cows compared with non-pregnant non-lactating cows. Of these, only the alterations in glucose, ketone bodies and urea concentrations and bromsulphthalein half-time and retention were markedly different before calving. The degree of fatty infiltration of the liver was significant two weeks before as well as two weeks after calving which differed from previous reports. It seems likely that the changes in the liver in dairy cows are functional and reversible and related to the metabolic demands of late pregnancy and early lactation. The results suggest that such changes in the liver occur well before calving.
研究了健康奶牛在妊娠后期以及产犊后肝功能可能发生改变的情况，并将结果与未怀孕未泌乳奶牛的结果进行了比较。与未怀孕未泌乳奶牛相比，围产期奶牛的血浆总胆红素、葡萄糖、总酮体和尿素浓度、溴磺酞清除率以及血浆天冬氨酸转氨酶和肌酸激酶活性均有显著改变。其中，只有葡萄糖、酮体和尿素浓度以及溴磺酞半衰期和潴留量的改变在产犊前有明显差异。产犊前两周和产犊后两周肝脏脂肪浸润程度均显著，这与之前的报道不同。奶牛肝脏的变化似乎是功能性的且可逆的，与妊娠后期和泌乳早期的代谢需求有关。结果表明，肝脏的这种变化在产犊前就已发生。
