Chen S L, Cai S R, Zhang X H, Peng J J, Li W F, Zhai E T, Chen J H, Wu H, Chen C Q, Ma J P, He Y L
Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou city, Guangdong Province, China.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):197-204.
The aim of this research was to study the clinical significance and expression of CD4+CD25+ regulatory T cells (Tregs) and p3Forkhead transcription factor-3 (Foxp3) in peripheral blood of patients with gastric carcinoma (GC) and to investigate the effects in the occurrence and development process of GC, to further comprehend their clinical values and provide a theoretical basis for the early diagnosis and immunotherapy of GC. The expression levels of CD4+CD25+Foxp3+Tregs in GC patients, at TNM staging, differentiated degree, lymphatic metastasis, cancer sites and cancer diameter of GC, were analyzed within the groups. The comparison of the expression levels of CD4+CD25+Foxp3+Tregs in peripheral blood between the GC group and the healthy control group showed a statistically significant difference. At TNM staging within the groups, pairwise comparisons of the expression levels of CD4+CD25+Foxp3+Tregs indicated that differences among the stage I+II group, stage III group and stage IV group were statistically significant. The expression levels of CD4+CD25+Foxp3+Tregs are closely relative to the occurrence and development of GC, providing theoretical bases and evidence for the early diagnosis, prognosis evaluation and immunotherapy of GC.
本研究旨在探讨胃癌（GC）患者外周血中CD4+CD25+调节性T细胞（Tregs）和p3叉头转录因子-3（Foxp3）的临床意义及表达情况，研究其在胃癌发生发展过程中的作用，进一步了解其临床价值，为胃癌的早期诊断和免疫治疗提供理论依据。分析了胃癌患者CD4+CD25+Foxp3+Tregs在TNM分期、分化程度、淋巴转移、癌灶部位及癌灶直径等分组情况下的表达水平。胃癌组与健康对照组外周血中CD4+CD25+Foxp3+Tregs表达水平比较，差异有统计学意义。组内TNM分期中，CD4+CD25+Foxp3+Tregs表达水平两两比较显示，Ⅰ+Ⅱ期组、Ⅲ期组和Ⅳ期组之间差异有统计学意义。CD4+CD25+Foxp3+Tregs表达水平与胃癌的发生发展密切相关，为胃癌的早期诊断、预后评估及免疫治疗提供了理论依据和证据。
