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自杀案例中抗抑郁药的诊断与处方:意大利弗留利-威尼斯朱利亚大区2002 - 2008年登记结果

Diagnoses and prescriptions of antidepressants in suicides: Register findings from the Friuli Venezia Giulia Region, Italy, 2002-2008.

作者信息

Castelpietra Giulio, Bovenzi Massimo, Clagnan Elena, Barbone Fabio, Balestrieri Matteo, Isacsson Göran

机构信息

a Department of Clinical Neuroscience , Karolinska Institutet , Stockholm , Sweden ;

b Central Health Directorate/Classification Area, Friuli Venezia Giulia Region , Italian Collaborating Centre for the WHO Family of International Classifications , Udine , Italy ;

出版信息

Int J Psychiatry Clin Pract. 2016;20(2):121-4. doi: 10.3109/13651501.2016.1149196. Epub 2016 Apr 7.

Abstract

OBJECTIVE

To explore to what extent and under which diagnoses individuals who committed suicide had received psychiatric in-patient care, and how many had previously committed non-lethal self-harm. To investigate the antidepressant treatment received by these individuals.

METHODS

Case-control study based on a health register.

RESULTS

Psychiatric hospitalisation was found in 31.2% of the cases and 2.3% of the controls, and was a strong predictor for suicide with an odds ratio (OR) = 19.5. This did not differ significantly between diagnostic categories (except anxiety disorders with OR = 5.3). Non-lethal self-harm in the study period was committed by 14.3% of the cases and 0.14% of the controls, and was twice as common in female cases than in male cases. Previous self-harm was a very strong independent predictor for suicide with OR = 53.1 when a single episode of self-harm had occurred, and OR = 98.0 for repeated episodes (adjusted for age, gender and hospitalisation). Only 16.1% of the cases were currently on antidepressant medication at the time of suicide.

CONCLUSIONS

Few of the suicides had previously been psychiatric in-patients. Even fewer had current prescriptions for antidepressants. This suggests that better diagnosis and treatment of psychiatric patients is an important suicide preventive intervention.

摘要

目的

探讨自杀者在何种程度上以及在哪些诊断下接受过精神科住院治疗,以及有多少人曾有过非致命性自我伤害行为。调查这些人接受的抗抑郁治疗情况。

方法

基于健康登记册的病例对照研究。

结果

31.2%的病例和2.3%的对照者曾有过精神科住院治疗,且这是自杀的一个强有力预测因素,优势比(OR)=19.5。不同诊断类别之间这一比例无显著差异(焦虑症除外,其OR = 5.3)。在研究期间,14.3%的病例和0.14%的对照者有过非致命性自我伤害行为,女性病例中的发生率是男性病例的两倍。既往有过自我伤害行为是自杀的一个非常强的独立预测因素,单次自我伤害发作时OR = 53.1,多次发作时OR = 98.0(根据年龄、性别和住院情况进行了调整)。自杀时仅有16.1%的病例正在服用抗抑郁药物。

结论

很少有自杀者此前是精神科住院患者。目前正在服用抗抑郁药物的人更少。这表明更好地诊断和治疗精神科患者是一项重要的自杀预防干预措施。

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