Kim Samuel W, Goedegebuure Peter, Gillanders William E
Department of Surgery, Washington University School of Medicine , St. Louis, MO, USA.
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA; The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO, USA.
Oncoimmunology. 2016 Feb 26;5(2):e1069940. doi: 10.1080/2162402X.2015.1069940. eCollection 2016 Feb.
We recently completed a phase 1 clinical trial demonstrating the safety of a mammaglobin-A DNA vaccine in patients with metastatic breast cancer. We are currently enrolling patients with early stage breast cancer in a phase 1b clinical trial. The mammaglobin-A DNA vaccine will be administered concurrently with neoadjuvant endocrine therapy, providing a unique opportunity to examine the impact of vaccination in the tumor microenvironment.
我们最近完成了一项1期临床试验，证明了乳腺珠蛋白-A DNA疫苗在转移性乳腺癌患者中的安全性。我们目前正在一项1b期临床试验中招募早期乳腺癌患者。乳腺珠蛋白-A DNA疫苗将与新辅助内分泌治疗同时给药，这为研究疫苗接种对肿瘤微环境的影响提供了独特的机会。
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