中国安庆市的空气污染与出生缺陷风险
Air Pollution and the Risk of Birth Defects in Anqing City, China.
作者信息
Yao Cijiang, Chen Yanyan, Zhu Xiaoxia, Liu Ying, Zhang Jian, Hou Lijuan, Xu Yachun, Zhang Chao, Cao Jiyu
机构信息
Department of Occupational and Environmental (Yao, Chen, Zhu, Liu, JZhang, Hou, Xu, CZhang, Cao), and The Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, China (Cao).
出版信息
J Occup Environ Med. 2016 Apr;58(4):e124-7. doi: 10.1097/JOM.0000000000000676.
OBJECTIVE
This study aimed to explore evidence for the influence of air pollution on the risk of birth defects in China and contribute to establish prevention strategies.
METHODS
We conducted a retrospective cohort study in Anqing city, Eastern China, from 2010 to 2012. Binary logistic regression models were used to estimate odds ratios (ORs) per 10 μg/m3 change for SO2, NO2, and PM10.
RESULTS
For continuous exposure to SO2 (10 μg/m increase), the adjusted OR for birth defects is 1.20 [95% confidence interval (95% CI) 1.09 to 1.29] in the preconception. A 10 μg/m increase in SO2 (adjusted OR 1.26, 95% CI 1.15 to 1.36) during the second trimester is strongly associated with birth defects. No associations have been observed for NO2 and PM10.
CONCLUSION
The results suggested that exposure to ambient SO2 during pregnancy may increase the risk of birth defects.
目的
本研究旨在探究空气污染对中国出生缺陷风险影响的证据，并为制定预防策略提供依据。
方法
我们于2010年至2012年在中国东部安庆市进行了一项回顾性队列研究。采用二元逻辑回归模型估计二氧化硫（SO₂）、二氧化氮（NO₂）和细颗粒物（PM₁₀）每变化10μg/m³时的比值比（OR）。
结果
对于孕前持续暴露于SO₂（每增加10μg/m³），出生缺陷的调整后OR为1.20[95%置信区间（95%CI）为1.09至1.29]。孕中期SO₂每增加10μg/m³（调整后OR为1.26，95%CI为1.15至1.36）与出生缺陷密切相关。未观察到NO₂和PM₁₀与出生缺陷有关联。
结论
结果表明孕期暴露于环境SO₂可能会增加出生缺陷风险。
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