香料成分互认组织（RIFM）香料成分安全评估，对异丙基苄基乙酸酯，化学物质登记号59230-57-8。
RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8.
作者信息
Api A M, Belsito D, Bhatia S, Bruze M, Calow P, Dagli M L, Dekant W, Fryer A D, Kromidas L, La Cava S, Lalko J F, Lapczynski A, Liebler D C, Politano V T, Ritacco G, Salvito D, Schultz T W, Shen J, Sipes I G, Wall B, Wilcox D K
机构信息
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
出版信息
Food Chem Toxicol. 2016 Nov;97S:S69-S79. doi: 10.1016/j.fct.2016.04.002. Epub 2016 Apr 5.
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
在当前使用条件下，现有信息支持该材料的使用。对该材料进行了遗传毒性、重复剂量毒性、发育毒性、生殖毒性、局部呼吸道毒性、光毒性、皮肤致敏性以及环境安全性评估。来自合适的交叉参照类似物乙酸苄酯（CAS编号：140-11-4）的数据表明，该材料无遗传毒性，也没有皮肤致敏潜力。使用乙酸苄酯（CAS编号：140-11-4）作为合适的交叉参照类似物完成了重复剂量、发育和生殖以及局部呼吸道毒性终点评估，得出的安全边际大于100。基于合适的紫外光谱完成了光毒性/光变应原性终点评估。按照RIFM框架中的描述完成了环境终点评估。
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