Stern D, Schoenlein R W, Puliafito C A, Dobi E T, Birngruber R, Fujimoto J G
Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
Arch Ophthalmol. 1989 Apr;107(4):587-92. doi: 10.1001/archopht.1989.01070010601038.
We produced corneal excisions with nanosecond (ns)-, picosecond-, and femtosecond (fs)-pulsed lasers at visible wavelengths. The threshold energy for ablation was proportional to the square root of the pulse duration and varied from 2.5 microjoules (microJ) at 100 fs to 500 microJ at 8 ns. Excisions made with picosecond and femtosecond lasers was ultrastructurally superior to those made with nanosecond lasers and, at pulse energies near threshold, showed almost as little tissue damage as excisions made with excimer lasers at 193 nm. We conclude that ultrashort-pulsed lasers at visible and near-infrared wavelengths are a possible alternative to excimer lasers for corneal surgery and might have advantages over conventional ophthalmic neodymium-YAG lasers for some intraocular applications.
我们使用可见波长的纳秒（ns）、皮秒和飞秒（fs）脉冲激光进行角膜切除术。消融的阈值能量与脉冲持续时间的平方根成正比，范围从100飞秒时的2.5微焦耳（μJ）到8纳秒时的500微焦耳。皮秒和飞秒激光制作的切除术在超微结构上优于纳秒激光制作的切除术，并且在接近阈值的脉冲能量下，与193纳米准分子激光制作的切除术相比，组织损伤几乎同样小。我们得出结论，可见和近红外波长的超短脉冲激光可能是准分子激光用于角膜手术的一种替代选择，并且在某些眼内应用中可能比传统眼科钕-YAG激光具有优势。
