Puliafito C A, Steinert R F, Deutsch T F, Hillenkamp F, Dehm E J, Adler C M
Ophthalmology. 1985 Jun;92(6):741-8. doi: 10.1016/s0161-6420(85)33962-3.
The pulsed ultraviolet excimer laser has been used to produce tissue ablation with a high degree of precision and with minimal thermal damage to adjacent structures. In comparative studies of excimer laser ablation of the cornea and crystalline lens using 193 nm and 248 nm radiation, threshold fluence for corneal and lens ablation was higher at 248 nm than at 193 nm. Ablation of corneal stroma at 193 nm produced the most precise cuts. When examined by transmission electron microscopy, a narrow zone of damaged tissue (0.1 to 0.3 micron) was seen immediately adjacent to the tissue removed by the laser. Ablation with 248 nm radiation produced incisions with ragged edges and with a wider and more severe zone of damage in adjacent stroma. Ultraviolet spectral transmission studies of the corneal stroma showed that absorption is 10 times greater at 193 nm than at 248 nm. The excimer laser was effective in producing well controlled ablation of the crystalline lens in vitro, with effects parallel to those seen in the cornea.
脉冲紫外准分子激光已被用于进行高度精确的组织消融，对相邻结构的热损伤最小。在使用193nm和248nm辐射对角膜和晶状体进行准分子激光消融的对比研究中，角膜和晶状体消融的阈值能量密度在248nm时高于193nm。193nm时对角膜基质的消融产生了最精确的切割。通过透射电子显微镜检查时，在紧邻激光切除组织的部位可见一个狭窄的受损组织区域（0.1至0.3微米）。248nm辐射消融产生的切口边缘参差不齐，相邻基质中的损伤区域更宽且更严重。角膜基质的紫外光谱透射研究表明，193nm处的吸收比248nm处大10倍。准分子激光在体外对晶状体进行良好控制的消融方面是有效的，其效果与在角膜中观察到的效果相似。
