Wang Ya-Wen, Chen Xu, Ma Rong, Gao Peng
Department of Pathology, School of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.
Tumour Biol. 2016 Jul;37(7):8487-502. doi: 10.1007/s13277-016-5050-x. Epub 2016 Apr 9.
cAMP response element binding protein 1 (CREB1, CREB) is a key transcription factor that mediates transcriptional responses to a variety of growth factors and stress signals. CREB1 has been shown to play a critical role in development and progression of tumors. MicroRNAs (miRNAs) are a class of non-coding RNAs. They post-transcriptionally regulate gene expression through pairing with the 3'-UTR of their target mRNAs and thus regulate initiation and progression of various types of human cancers. Recent studies have demonstrated that a number of miRNAs can be transcriptionally regulated by CREB1. Interestingly, CREB1 expression can also be modulated by miRNAs, thus forming a feedback loop. This review outlines the functional roles of CREB1, miRNA, and their interactions in human malignancies. This will help to define a relationship between CREB1 and miRNA in human cancer and develop novel therapeutic strategies.
环磷腺苷效应元件结合蛋白1（CREB1，即CREB）是一种关键的转录因子，可介导对多种生长因子和应激信号的转录反应。CREB1已被证明在肿瘤的发生和发展中起关键作用。微小RNA（miRNA）是一类非编码RNA。它们通过与靶mRNA的3'-非翻译区配对在转录后调节基因表达，从而调节各种类型人类癌症的发生和发展。最近的研究表明，许多miRNA可被CREB1转录调控。有趣的是，CREB1的表达也可被miRNA调节，从而形成一个反馈环。本综述概述了CREB1、miRNA及其在人类恶性肿瘤中的相互作用的功能作用。这将有助于明确人类癌症中CREB1与miRNA之间的关系，并开发新的治疗策略。
