Department of hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China.
Department of hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China.
Gene. 2018 Sep 25;672:56-63. doi: 10.1016/j.gene.2018.06.005. Epub 2018 Jun 4.
Ecotropic virus integration site-1 (EVI1) is an oncogenic transcription factor which locus on chromosome 3(3q26.2). Alterations in EVI1 functions correspond with poor prognosis in different cancers, underscoring their status for the clinical cancer phenotype. MicroRNAs(MiR)are a class of small non-coding RNA sequences. They post-transcriptionally influence mRNA sequence through imperfect pairing with the 3'-UTR. Moreover, a growing body of studies showed that miRNAs could regulate initiation and progression of human malignancies. Current studies have been described that identifies numerous microRNAs that can be modulated by EVI1. Interestingly, the expression level of EVI1 can also be regulated by microRNAs, thus forming a reciprocal link. Recent understanding of the functional roles of EVI1, microRNAs, and their interactions in human cancers are summarized. This review will help to define a relationship between EVI1 and microRNAs in human malignancies and develop novel therapeutic strategies.
嗜同性病毒整合位点 1（EVI1）是一种致癌转录因子，其位于染色体 3（3q26.2）上。EVI1 功能的改变与不同癌症的预后不良相对应，突出了它们在临床癌症表型中的地位。MicroRNAs（miRNA）是一类小的非编码 RNA 序列。它们通过与 3'UTR 的不完全配对来影响 mRNA 序列的转录后。此外，越来越多的研究表明，miRNA 可以调节人类恶性肿瘤的发生和发展。目前的研究已经描述了许多可以被 EVI1 调节的 microRNAs。有趣的是，EVI1 的表达水平也可以被 microRNAs 调节，从而形成一个相互关联的环节。本文总结了 EVI1、microRNAs 及其在人类癌症中的相互作用的功能作用的最新认识。这篇综述将有助于确定 EVI1 和 microRNAs 在人类恶性肿瘤中的关系，并开发新的治疗策略。
