5-甲基四氢叶酸合成的调控
Regulation of 5-methyltetrahydrofolate synthesis.
作者信息
Lumb M, Bottiglieri T, Deacon R, Perry J, Chanarin I
机构信息
Haematology Section, M.R.C. Clinical Research Centre, Northwick Park Hospital, Harrow, Middx., U.K.
出版信息
Biochem J. 1989 Mar 1;258(2):611-2. doi: 10.1042/bj2580611.
Abstract
After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the methylfolate level starts 2.5 h after the methionine injection, when the hepatic methionine level and the S-adenosylmethionine/S-adenosylhomocysteine ratio have returned to baseline values. S-Adenosylmethionine concentration is still elevated at this time.
摘要
给大鼠腹腔注射100微摩尔甲硫氨酸后，肝脏5-甲基四氢叶酸的甲基迅速氧化形成甲酸和二氧化碳。甲硫氨酸注射后2.5小时开始恢复甲基叶酸水平，此时肝脏甲硫氨酸水平以及S-腺苷甲硫氨酸/S-腺苷高半胱氨酸比值已恢复至基线值。此时S-腺苷甲硫氨酸浓度仍处于升高状态。
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