Chapuis Alexandra, Chabrot Cécile, Mirand Audrey, Poirier Philippe, Nourrisson Céline
Laboratoire de Parasitologie-Mycologie, Centre de Biologie, CHU Gabriel Montpied, 58, rue Montalembert, F-63003 Clermont-Ferrand, France.
Service d'Hématologie clinique et Thérapie cellulaire, CHU Estaing, Clermont-Ferrand, France.
Int J Infect Dis. 2016 May;46:79-81. doi: 10.1016/j.ijid.2016.04.002. Epub 2016 Apr 6.
The case of a central nervous system human herpes virus type 6 (HHV-6) and Toxoplasma gondii co-infection after an umbilical cord blood transplantation in a chronic myelomonocytic leukaemia patient is reported.
A 65-year-old Caucasian man underwent an umbilical cord blood transplantation within the context of chronic myelomonocytic leukaemia. On day 37 post-graft, he presented with a severe headache; PCRs of cerebrospinal fluid and blood were positive for T. gondii and HHV-6. The patient was treated with pyrimethamine and sulfadiazine associated with ganciclovir.
HHV-6 reactivation can trigger a reactivation of T. gondii. This case suggests that patients who are seropositive for T. gondii and who present with HHV-6 reactivation should be monitored closely for toxoplasmosis.
报告了1例慢性粒单核细胞白血病患者在脐带血移植后发生中枢神经系统人类疱疹病毒6型（HHV-6）和弓形虫双重感染的病例。
一名65岁的白种男性在慢性粒单核细胞白血病背景下接受了脐带血移植。移植后第37天，他出现严重头痛；脑脊液和血液的聚合酶链反应显示弓形虫和HHV-6呈阳性。患者接受了乙胺嘧啶、磺胺嘧啶联合更昔洛韦治疗。
HHV-6再激活可引发弓形虫再激活。该病例表明，弓形虫血清学阳性且出现HHV-6再激活的患者应密切监测是否发生弓形虫病。
