Fuehrlein Brian S, Mota Natalie, Arias Albert J, Trevisan Louis A, Kachadourian Lorig K, Krystal John H, Southwick Steven M, Pietrzak Robert H
VA Connecticut Healthcare System, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Addiction. 2016 Oct;111(10):1786-94. doi: 10.1111/add.13423. Epub 2016 May 26.
To analyze data from a large, contemporary, nationally representative sample of US veterans to evaluate: (1) the prevalence of life-time alcohol use disorder (AUD) and past-year AUD; (2) common psychiatric comorbidities associated with life-time AUD; and (3) correlates of life-time and past-year probable AUD.
Data were analyzed from the National Health and Resilience in Veterans Study (NHRVS), a web-based survey of a random probability sample of a contemporary, nationally representative sample of US military veterans.
United States.
Nationally representative sample of 3157 US veterans aged 21 years and older.
Life-time alcohol abuse and dependence were assessed according to DSM-IV diagnostic criteria using the Mini International Neuropsychiatric Interview, and combined into a single variable: AUD. Past-year probable AUD was assessed using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Correlates of AUD, including psychiatric comorbidities, suicidality and demographic characteristics, were also assessed.
The prevalence of life-time AUD and past-year probable AUD was 42.2% [95% confidence interval (CI) = 40.5-43.9%)] and 14.8% (95% CI = 13.6-16.0%), respectively. Compared with veterans without AUD, those with life-time AUD had substantially elevated rates of life-time and current mood and anxiety disorders [odds ratios (ORs) = 2.6-4.1], drug use disorder (OR = 10.7), life-time suicide attempt (OR = 4.1) and current suicidal ideation (OR = 2.1). Younger age, male sex, lower education, lower annual household income and greater number of life-time traumatic events were associated independently with life-time AUD. Younger age, male sex, unpartnered marital status and a life-time diagnosis of major depressive disorder were associated independently with past-year probable AUD.
More than 40% of US military veterans have a life-time history of alcohol use disorder. Veterans with a life-time history of alcohol use disorder have substantial comorbid psychiatric burden, including elevated rates of suicidal ideation and attempts. Certain socio-demographic (e.g. younger age, male sex, lower education) and clinical (e.g. trauma burden, history of depression) characteristics are associated with increased risk of AUD.
分析来自美国退伍军人的一个大型、当代、具有全国代表性样本的数据，以评估：（1）终生酒精使用障碍（AUD）和过去一年AUD的患病率；（2）与终生AUD相关的常见精神共病；（3）终生和过去一年可能的AUD的相关因素。
数据来自退伍军人健康与恢复力研究（NHRVS），这是一项基于网络的调查，对当代具有全国代表性的美国退伍军人随机概率样本进行调查。
美国。
3157名年龄在21岁及以上的具有全国代表性的美国退伍军人样本。
根据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断标准，使用迷你国际神经精神访谈评估终生酒精滥用和依赖情况，并合并为一个单一变量：AUD。使用酒精使用障碍识别测试-消费量（AUDIT-C）评估过去一年可能的AUD。还评估了AUD的相关因素，包括精神共病、自杀倾向和人口统计学特征。
终生AUD和过去一年可能的AUD的患病率分别为42.2%[95%置信区间（CI）=40.5-43.9%]和14.8%（95%CI=13.6-16.0%）。与没有AUD的退伍军人相比，有终生AUD的退伍军人终生和当前情绪及焦虑障碍[优势比（OR）=2.6-4.1]、药物使用障碍（OR=10.7）、终生自杀未遂（OR=4.1）和当前自杀意念（OR=2.1）的发生率大幅升高。年龄较小、男性、教育程度较低、家庭年收入较低以及终生创伤事件数量较多与终生AUD独立相关。年龄较小、男性、未婚婚姻状况和终生重度抑郁症诊断与过去一年可能的AUD独立相关。
超过40%的美国退伍军人有终生酒精使用障碍病史。有终生酒精使用障碍病史的退伍军人有相当大的精神共病负担，包括自杀意念和未遂发生率升高。某些社会人口学（如年龄较小、男性、教育程度较低）和临床（如创伤负担、抑郁症病史）特征与AUD风险增加相关。
