非洛地平在肾功能受损患者中的药代动力学。
Pharmacokinetics of felodipine in patients with impaired renal function.
作者信息
Edgar B, Regårdh C G, Attman P O, Aurell M, Herlitz H, Johnsson G
机构信息
Department of Clinical Pharmacology, University of Göteborg, Sweden.
出版信息
Br J Clin Pharmacol. 1989 Jan;27(1):67-74. doi: 10.1111/j.1365-2125.1989.tb05336.x.
Abstract
- The pharmacokinetics of felodipine and its effects on blood pressure and heart rate were studied in eight male patients aged between 28 and 57 years with a glomerular filtration rate, GFR, between 8 and 68 ml min-1, following single i.v. and oral administration. 2. Clearance, Cmax, AUC, Vss and V, of felodipine were unaffected by the renal disease. The metabolite excretion (14C-labelled) was slower than in healthy subjects. Initial renal clearance of these metabolites correlated with individual GFR values. The total amount of the dose excreted in the urine was also decreased.
摘要
- 在8名年龄在28至57岁之间、肾小球滤过率（GFR）在8至68毫升/分钟之间的男性患者中，研究了非洛地平的药代动力学及其对血压和心率的影响，给药方式为单次静脉注射和口服。2. 非洛地平的清除率、Cmax、AUC、稳态分布容积（Vss）和分布容积（V）不受肾脏疾病影响。代谢物排泄（14C标记）比健康受试者慢。这些代谢物的初始肾清除率与个体GFR值相关。尿液中排泄的剂量总量也减少了。
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