Department of Cardiology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.
School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Nephrology (Carlton). 2016 Oct;21(10):901-4. doi: 10.1111/nep.12792.
In this prospective observational cohort study, we evaluate the change in cardiovascular risk parameters, with a focus on lipids, in live kidney donors 1 year post donation. Body mass index, systolic/diastolic blood pressure, kidney function (chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration) and lipid parameters were measured at baseline and 1 year. Data on 87 live kidney donors were collected. Body mass index increased from 26.5 ± 2.7 pre to 27.4 ± 3.0 kg/m(2) post donation (p < 0.0001). Chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration decreased from 111.8 ± 20.0 pre to 72.1 ± 13.1 mL/min/1.73 m(2) post donation (p < 0.0001). Serum triglyceride levels increased from 0.8 (interquartile range 0.6-1.3) pre to 1.0 mmol/L (interquartile range 0.7-1.6) post donation (p = 0.0004). Statin use increased from 11.5% pre to 21% post donation (p < 0.005). Low-density lipoprotein remained stable, and other lipids (high-density lipoprotein, apolipoprotein B and lipoprotein a) did not change post donation.
在这项前瞻性观察队列研究中，我们评估了活体肾捐献者在捐献后 1 年内心血管风险参数的变化，重点关注脂质。在基线和 1 年时测量了体重指数、收缩压/舒张压、肾功能（铬-51 乙二胺四乙酸估计肾小球滤过率）和脂质参数。收集了 87 名活体肾捐献者的数据。体重指数从捐赠前的 26.5±2.7kg/m2增加到捐赠后的 27.4±3.0kg/m2（p<0.0001）。铬-51 乙二胺四乙酸估计肾小球滤过率从捐赠前的 111.8±20.0ml/min/1.73m2下降到捐赠后的 72.1±13.1ml/min/1.73m2（p<0.0001）。血清三酰甘油水平从捐赠前的 0.8（四分位间距 0.6-1.3）mmol/L增加到 1.0mmol/L（四分位间距 0.7-1.6）mmol/L（p=0.0004）。他汀类药物的使用率从捐赠前的 11.5%上升到捐赠后的 21%（p<0.005）。低密度脂蛋白保持稳定，其他脂质（高密度脂蛋白、载脂蛋白 B 和脂蛋白 a）在捐赠后没有变化。
