活体供者研究 - 肾脏捐献对心血管风险的影响，重点关注包括脂蛋白(a)在内的脂质参数。
Live donor study - implications of kidney donation on cardiovascular risk with a focus on lipid parameters including lipoprotein a.
机构信息
Department of Cardiology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.
School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
出版信息
Nephrology (Carlton). 2016 Oct;21(10):901-4. doi: 10.1111/nep.12792.
In this prospective observational cohort study, we evaluate the change in cardiovascular risk parameters, with a focus on lipids, in live kidney donors 1 year post donation. Body mass index, systolic/diastolic blood pressure, kidney function (chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration) and lipid parameters were measured at baseline and 1 year. Data on 87 live kidney donors were collected. Body mass index increased from 26.5 ± 2.7 pre to 27.4 ± 3.0 kg/m(2) post donation (p < 0.0001). Chromium-51 ethylenediaminetetraacetic acid estimated glomerular filtration decreased from 111.8 ± 20.0 pre to 72.1 ± 13.1 mL/min/1.73 m(2) post donation (p < 0.0001). Serum triglyceride levels increased from 0.8 (interquartile range 0.6-1.3) pre to 1.0 mmol/L (interquartile range 0.7-1.6) post donation (p = 0.0004). Statin use increased from 11.5% pre to 21% post donation (p < 0.005). Low-density lipoprotein remained stable, and other lipids (high-density lipoprotein, apolipoprotein B and lipoprotein a) did not change post donation.
在这项前瞻性观察队列研究中，我们评估了活体肾捐献者在捐献后 1 年内心血管风险参数的变化，重点关注脂质。在基线和 1 年时测量了体重指数、收缩压/舒张压、肾功能（铬-51 乙二胺四乙酸估计肾小球滤过率）和脂质参数。收集了 87 名活体肾捐献者的数据。体重指数从捐赠前的 26.5±2.7kg/m2增加到捐赠后的 27.4±3.0kg/m2（p<0.0001）。铬-51 乙二胺四乙酸估计肾小球滤过率从捐赠前的 111.8±20.0ml/min/1.73m2下降到捐赠后的 72.1±13.1ml/min/1.73m2（p<0.0001）。血清三酰甘油水平从捐赠前的 0.8（四分位间距 0.6-1.3）mmol/L增加到 1.0mmol/L（四分位间距 0.7-1.6）mmol/L（p=0.0004）。他汀类药物的使用率从捐赠前的 11.5%上升到捐赠后的 21%（p<0.005）。低密度脂蛋白保持稳定，其他脂质（高密度脂蛋白、载脂蛋白 B 和脂蛋白 a）在捐赠后没有变化。
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