Pennycuff Jon F, Schutte Stacey C, Hudson Catherine O, Karp Deborah R, Malykhina Anna P, Northington Gina M
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
Division of Urology, Department of Surgery, University of Colorado Denver School of Medicine, Denver, Colombia.
Neurourol Urodyn. 2017 Mar;36(3):740-744. doi: 10.1002/nau.23011. Epub 2016 Apr 6.
The aim of this study was to compare the expression of urinary nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), substance P (SP), and calcitonin-gene related peptide (CGRP) in women with and without overactive bladder (OAB). We sought to determine factors associated with higher expression of these neuropeptides.
Participants with OAB and age-matched controls were enrolled. Symptom severity was assessed with validated questionnaires. Urinary neurotrophin levels, symptom scores, and clinical data were compared between the groups. Multivariate analysis determined independent factors associated with urinary neurotrophin levels.
Sixty-seven women (38 OAB, 29 controls) were included. Women with OAB and controls were similar in age, race, body mass index, parity, and smoking status. Women with OAB were more likely to report a history of pelvic pain and pelvic surgery. Neurotrophic factor levels normalized to urinary creatinine did not differ between the groups. Increasing age was associated with greater urinary levels of BDNF and NGF (β = 0.23, 95%CI 0.11-0.34 and 0.75, 95%CI 0.17-1.33, respectively, P < 0.02). Higher urinary NGF was associated with increasing BMI (β = 0.81, 95%CI 0.05-1.57, P = 0.04) while pain was associated with elevated urinary SP (β = 0.21, 95%CI 0.09-0.33, P = 0.001).
Our data does not support a relationship between urinary neurotrophin levels and OAB in age-matched postmenopausal women. Further research is necessary to elucidate the role of urinary neurotrophins in the diagnosis and management of OAB. Neurourol. Urodynam. 36:740-744, 2017. © 2016 Wiley Periodicals, Inc.
本研究旨在比较有和没有膀胱过度活动症（OAB）的女性中尿神经生长因子（NGF）、脑源性神经营养因子（BDNF）、P物质（SP）和降钙素基因相关肽（CGRP）的表达。我们试图确定与这些神经肽高表达相关的因素。
招募患有OAB的参与者和年龄匹配的对照组。使用经过验证的问卷评估症状严重程度。比较两组之间的尿神经营养素水平、症状评分和临床数据。多变量分析确定与尿神经营养素水平相关的独立因素。
纳入67名女性（38名OAB患者，29名对照）。患有OAB的女性和对照组在年龄、种族、体重指数、产次和吸烟状况方面相似。患有OAB的女性更有可能报告有盆腔疼痛和盆腔手术史。以尿肌酐标准化后的神经营养因子水平在两组之间没有差异。年龄增加与尿BDNF和NGF水平升高相关（β分别为0.23，95%CI 0.11 - 0.34和0.75，95%CI 0.17 - 1.33，P < 0.02）。较高的尿NGF与体重指数增加相关（β = 0.81，95%CI 0.05 - 1.57，P = 0.04），而疼痛与尿SP升高相关（β = 0.21，95%CI 0.09 - 0.33，P = 0.001）。
我们的数据不支持在年龄匹配的绝经后女性中尿神经营养素水平与OAB之间存在关联。需要进一步研究以阐明尿神经营养素在OAB诊断和管理中的作用。《神经泌尿学与尿动力学》36:740 - 744，2017。© 2016威利期刊公司。
