Jankiewicz Katarzyna, Bogusiewicz Michał, Nowakowski Łukasz, Rechberger Tomasz, Rogowski Artur, Miotla Pawel
2nd Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland.
1st Military Clinical Hospital with Polyclinic, 20-049 Lublin, Poland.
J Clin Med. 2022 Feb 13;11(4):971. doi: 10.3390/jcm11040971.
(1) Background: Overactive bladder (OAB) symptoms are frequently present in women with pelvic organ prolapse (POP). Although urinary nerve growth factor (NGF) is a promising biomarker of OAB, little is known about its role in patients with OAB secondary to POP. The aim of the study was to evaluate urinary NGF levels in patients with POP involving the anterior vaginal wall and check if it may serve as a predicting factor for postoperative resolution of OAB symptoms. (2) Methods: Eighty-three Caucasian women included in the study were divided into three groups: pure OAB, one associated with POP (POP&OAB) and a control group composed of healthy volunteers. The urine NGF and creatinine were assessed with ELISA tests to calculate the NGF/creatinine ratio. (3) Results: The NGF/creatinine ratio was significantly higher in patients with pure OAB in comparison with other groups; however, it did not differ between the control group and the POP&OAB group. There was no correlation between NGF/creatinine ratio and age, menopausal status, BMI, parity or urodynamic findings. The NGF/creatinine ratio was not a prognostic factor for OAB symptoms' resolution after surgical treatment of POP. (4) Conclusions: Urinary NGF excretion is not increased in women with OAB secondary to POP; thus, it may not serve as an OAB biomarker in these patients.
(1) 背景：膀胱过度活动症（OAB）症状在盆腔器官脱垂（POP）女性中很常见。尽管尿神经生长因子（NGF）是一种很有前景的OAB生物标志物，但对于其在继发于POP的OAB患者中的作用知之甚少。本研究的目的是评估涉及阴道前壁的POP患者的尿NGF水平，并检查其是否可作为OAB症状术后缓解的预测因素。(2) 方法：纳入研究的83名白种女性被分为三组：单纯OAB组、与POP相关的一组（POP&OAB组）以及由健康志愿者组成的对照组。通过酶联免疫吸附测定（ELISA）试验评估尿NGF和肌酐水平，以计算NGF/肌酐比值。(3) 结果：与其他组相比，单纯OAB患者的NGF/肌酐比值显著更高；然而，对照组和POP&OAB组之间无差异。NGF/肌酐比值与年龄、绝经状态、体重指数、产次或尿动力学检查结果之间无相关性。NGF/肌酐比值不是POP手术治疗后OAB症状缓解的预后因素。(4) 结论：继发于POP的OAB女性的尿NGF排泄未增加；因此，它可能不是这些患者的OAB生物标志物。
