Voldby René Gren Hansen, Bajalan Salar
Ugeskr Laeger. 2016 Feb 22;178(8):V09150705.
Epileptics are often treated long-term with antiepileptic drugs (AED) of which some are suspected to cause reduction in bone mineral density (BMD). Lamotrigine might not have this effect. In this case report a 51-year-old epileptic woman who had normal BMD level was treated with lamotrigine and sustained an atypical femoral fracture (AFF) after a low-energy trauma. AFF have been associated with treatment with bisphosphonate, but never with treatment with lamotrigine or other AED's. However, this case report shows that AFF might be associated to treatment with lamotrigine. The possible correlation calls for further investigation.
癫痫患者通常长期使用抗癫痫药物（AED）进行治疗，其中一些药物被怀疑会导致骨矿物质密度（BMD）降低。拉莫三嗪可能没有这种作用。在本病例报告中，一名骨矿物质密度水平正常的51岁癫痫女性接受了拉莫三嗪治疗，在经历低能量创伤后发生了非典型股骨骨折（AFF）。AFF与双膦酸盐治疗有关，但从未与拉莫三嗪或其他抗癫痫药物治疗有关。然而，本病例报告表明，AFF可能与拉莫三嗪治疗有关。这种可能的相关性需要进一步研究。
