Cohen Steven P, Chaudhry Hira
a Departments of Anesthesiology & Critical Care Medicine and Physical Medicine & Rehabilitation , Johns Hopkins School of Medicine , Baltimore , MD , USA.
b Anesthesiology and Physical Medicine and Rehabilitation , Uniformed Services University of the Health Sciences , Bethesda , MD , USA.
Expert Rev Neurother. 2016 Jun;16(6):615-24. doi: 10.1080/14737175.2016.1175302. Epub 2016 Apr 18.
Migraine is a common and debilitating condition affecting approximately nearly one in four women in the USA and Europe. Episodic attacks can be associated with a number of symptoms, with nausea and/or vomiting being among the most frequent and distressing. Sumatriptan is widely used for acute treatment of migraine and is available in several formulations. The efficacy of oral sumatriptan is well-established. However, patients who experience migraine-associated nausea and/or vomiting can have difficulty swallowing tablets and may delay taking anti-migraine medication. In addition, absorption of oral sumatriptan can be reduced by migraine-associated gastroparesis. Non-oral formulations of sumatriptan are recommended for patients with nausea and/or vomiting, but their use may be limited by adverse effects and patient acceptance. A new transdermal formulation of sumatriptan has recently become available in the USA for acute treatment of migraine in adults. In this article, we review the properties of the sumatriptan iontophoretic transdermal patch and discuss the evidence to support its use in clinical practice.
偏头痛是一种常见且使人衰弱的疾病，在美国和欧洲，约每四名女性中就有近一人受其影响。发作性头痛可伴有多种症状，恶心和/或呕吐是最常见且令人苦恼的症状之一。舒马曲坦被广泛用于偏头痛的急性治疗，有多种剂型。口服舒马曲坦的疗效已得到充分证实。然而，经历偏头痛相关恶心和/或呕吐的患者可能难以吞咽片剂，并且可能延迟服用抗偏头痛药物。此外，偏头痛相关的胃轻瘫会降低口服舒马曲坦的吸收。对于有恶心和/或呕吐的患者，推荐使用舒马曲坦的非口服剂型，但它们的使用可能会受到不良反应和患者接受度的限制。一种新的舒马曲坦透皮制剂最近在美国上市，用于成人偏头痛的急性治疗。在本文中，我们回顾了舒马曲坦离子导入透皮贴剂的特性，并讨论了支持其在临床实践中使用的证据。
