Schlagowski Anna-Isabel, Isner-Horobeti Marie-Eve, Dufour Stéphane P, Rasseneur Laurence, Enache Irina, Lonsdorfer-Wolf Evelyne, Doutreleau Stéphane, Charloux Anne, Goupilleau Fabienne, Bentz Isabelle, Charles Anne Laure, Kouassi Blah Y, Zoll Joffrey, Geny Bernard, Favret Fabrice
Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.
CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France.
Muscle Nerve. 2016 Nov;54(5):925-935. doi: 10.1002/mus.25144. Epub 2016 Aug 31.
The goal of this study was to compare the effects of downhill (DH), uphill (UH), and UH-DH exercise training, at the same metabolic rate, on exercise capacity and skeletal muscle mitochondrial function.
Thirty-two Wistar rats were separated into a control and 3 trained groups. The trained groups exercised for 4 weeks, 5 times per week at the same metabolic rate, either in UH, DH, or combined UH-DH. Twenty-four hours after the last training session, the soleus, gastrocnemius, and vastus intermedius muscles were removed for assessment of mitochondrial respiration.
Exercise training, at the same metabolic rate, improved maximal running speed without specificity for exercise modalities. Maximal fiber respiration was enhanced in soleus and vastus intermedius in the UH group only.
Exercise training, performed at the same metabolic rate, improved exercise capacity, but only UH-trained rats enhanced mitochondrial function in both soleus and vastus intermedius skeletal muscle. Muscle Nerve 54: 925-935, 2016.
本研究的目的是比较在相同代谢率下，下坡（DH）、上坡（UH）以及上坡-下坡（UH-DH）运动训练对运动能力和骨骼肌线粒体功能的影响。
32只Wistar大鼠被分为对照组和3个训练组。训练组以相同代谢率每周进行5次运动训练，持续4周，训练方式分别为UH、DH或联合UH-DH。最后一次训练后24小时，取出比目鱼肌、腓肠肌和股中间肌用于评估线粒体呼吸。
在相同代谢率下进行运动训练可提高最大跑步速度，且对运动方式无特异性。仅UH组的比目鱼肌和股中间肌的最大纤维呼吸增强。
在相同代谢率下进行运动训练可提高运动能力，但只有接受UH训练的大鼠比目鱼肌和股中间肌的线粒体功能增强。《肌肉与神经》54: 925 - 935, 2016年。
