Penner Jacob, Ford Kristen A, Taylor Reggie, Schaefer Betsy, Théberge Jean, Neufeld Richard W J, Osuch Elizabeth A, Menon Ravi S, Rajakumar Nagalingam, Allman John M, Williamson Peter C
Department of Psychiatry, University of Western Ontario, LondonON, Canada; Imaging Division, Lawson Health Research Institute, LondonON, Canada; First Episode Mood and Anxiety Program, London Health Sciences Centre, LondonON, Canada.
Imaging Division, Lawson Health Research Institute, LondonON, Canada; Department of Medical Biophysics, University of Western Ontario, LondonON, Canada.
Front Hum Neurosci. 2016 Mar 30;10:132. doi: 10.3389/fnhum.2016.00132. eCollection 2016.
Anomalies in the medial prefrontal cortex, anterior insulae, and large-scale brain networks associated with them have been proposed to underlie the pathophysiology of schizophrenia and major depressive disorder (MDD). In this study, we examined the connectivity of the medial prefrontal cortices and anterior insulae in 24 healthy controls, 24 patients with schizophrenia, and 24 patients with MDD early in illness with seed-based resting state functional magnetic resonance imaging analysis using Statistical Probability Mapping. As hypothesized, reduced connectivity was found between the medial prefrontal cortex and the dorsal anterior cingulate cortex and other nodes associated with directed effort in patients with schizophrenia compared to controls while patients with MDD had reduced connectivity between the medial prefrontal cortex and ventral prefrontal emotional encoding regions compared to controls. Reduced connectivity was found between the anterior insulae and the medial prefrontal cortex in schizophrenia compared to controls, but contrary to some models emotion processing regions failed to demonstrate increased connectivity with the medial prefrontal cortex in MDD compared to controls. Although, not statistically significant after correction for multiple comparisons, patients with schizophrenia tended to demonstrate decreased connectivity between basal ganglia-thalamocortical regions and the medial prefrontal cortex compared to patients with MDD, which might be expected as these regions effect action. Results were interpreted to support anomalies in nodes associated with directed effort in schizophrenia and nodes associated with emotional encoding network in MDD compared to healthy controls.
内侧前额叶皮质、前岛叶以及与之相关的大规模脑网络异常被认为是精神分裂症和重度抑郁症（MDD）病理生理学的基础。在本研究中，我们使用统计概率图谱基于种子点的静息态功能磁共振成像分析，对24名健康对照者、24名精神分裂症患者和24名疾病早期的MDD患者的内侧前额叶皮质和前岛叶的连通性进行了检查。正如所假设的那样，与对照组相比，精神分裂症患者的内侧前额叶皮质与背侧前扣带回皮质以及其他与定向努力相关的节点之间的连通性降低，而MDD患者与对照组相比，内侧前额叶皮质与腹侧前额叶情绪编码区域之间的连通性降低。与对照组相比，精神分裂症患者的前岛叶与内侧前额叶皮质之间的连通性降低，但与一些模型相反，MDD患者与对照组相比，情绪处理区域与内侧前额叶皮质之间的连通性并未增加。尽管在进行多重比较校正后无统计学意义，但与MDD患者相比，精神分裂症患者的基底神经节 - 丘脑皮质区域与内侧前额叶皮质之间的连通性倾向于降低，鉴于这些区域影响行动，这可能是预期的。结果被解释为支持与健康对照相比，精神分裂症中与定向努力相关的节点以及MDD中与情绪编码网络相关的节点存在异常。
