Chertkow H, Bub D, Seidenberg M
Department of Neurolinguistics, Montreal Neurological Institute, Quebec, Canada.
Brain Lang. 1989 Apr;36(3):420-46. doi: 10.1016/0093-934x(89)90078-3.
Semantic memory (SM) was investigated in six patients with probable Alzheimer's disease (AD) by on-line measurement of semantic priming in a lexical decision task, and off-line tests of comprehension. Detailed assessment was carried out on naming, name comprehension, and probes of semantic knowledge with a battery of 150 items. The patients performed normally on perceptual tests and displayed an item-specific loss of knowledge on the semantic tests. In a primed lexical decision task, greater semantic priming was found relative to age-matched normals. The priming was substantially greater for items with "degraded" representations as determined by the off-line tests. Lexical decision was also performed more slowly on these items. These unexpected results demand a reevaluation of the concepts of the lexicon and semantic memory structure and their possible alteration in dementia.
通过在词汇判断任务中对语义启动的在线测量以及理解的离线测试，对6名可能患有阿尔茨海默病（AD）的患者的语义记忆（SM）进行了研究。使用一组150个项目对命名、名称理解和语义知识探测进行了详细评估。患者在感知测试中表现正常，但在语义测试中表现出特定项目的知识缺失。在启动的词汇判断任务中，相对于年龄匹配的正常人，发现了更大的语义启动效应。对于离线测试确定为具有“退化”表征的项目，启动效应显著更大。在这些项目上，词汇判断的执行速度也更慢。这些意外结果需要重新评估词汇和语义记忆结构的概念及其在痴呆症中可能发生的改变。
