Lopes-Pacheco Miquéias, Bandeira Elga, Morales Marcelo M
Laboratory of Cellular and Molecular Physiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Stem Cells Int. 2016;2016:5091838. doi: 10.1155/2016/5091838. Epub 2016 Mar 15.
Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence in developing countries. To date, there is no effective treatment to halt or reverse the disease progression caused by silica-induced lung injury. Significant advances have to be made in order to reduce morbidity and mortality related to silicosis. In this review, we have highlighted the main mechanisms of action that cause lung damage by silica particles and summarized the data concerning the therapeutic promise of cell-based therapy for silicosis.
矽肺是全球最常见的尘肺病，在发展中国家的患病率和发病率更高。迄今为止，尚无有效的治疗方法来阻止或逆转由二氧化硅引起的肺损伤所导致的疾病进展。为了降低与矽肺相关的发病率和死亡率，必须取得重大进展。在这篇综述中，我们重点介绍了二氧化硅颗粒导致肺损伤的主要作用机制，并总结了有关基于细胞的疗法治疗矽肺的前景的数据。
