军团菌肺炎伴肾磷酸盐排泄增加所致低磷血症两例
Two Cases of Hypophosphatemia with Increased Renal Phosphate Excretion in Legionella Pneumonia.
作者信息
Watanabe Shuhei, Kono Keiji, Fujii Hideki, Nakai Kentaro, Goto Shunsuke, Nishi Shinichi
机构信息
Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Nephrology, Akashi Medical Center, Akashi, Japan.
Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Case Rep Nephrol Dial. 2016 Mar 18;6(1):40-5. doi: 10.1159/000444875. eCollection 2016 Jan-Apr.
We encountered 2 cases of hypophosphatemia due to Legionella pneumonia. Both cases showed increased urinary phosphate excretion and renal tubular dysfunction, which ameliorated with recovery from Legionella pneumonia. Serum fibroblast growth factor-23 level was suppressed, whereas serum 1,25(OH)2 vitamin D and parathyroid hormone levels were normal. Delayed elevation of serum 1,25(OH)2 vitamin D levels was observed with improvement in renal tubular function. These findings suggested hypophosphatemia might be mediated by renal tubular dysfunction.
我们遇到了2例因军团菌肺炎导致的低磷血症病例。两例均表现为尿磷排泄增加和肾小管功能障碍，随着军团菌肺炎的康复而改善。血清成纤维细胞生长因子-23水平受到抑制，而血清1,25(OH)₂维生素D和甲状旁腺激素水平正常。随着肾小管功能的改善，观察到血清1,25(OH)₂维生素D水平延迟升高。这些发现提示低磷血症可能由肾小管功能障碍介导。
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