携带来自大肠杆菌的blaCTX-M-55、oqxAB、fosA3和floR的FII质粒p42-2的完整序列
Complete Sequence of the FII Plasmid p42-2, Carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli.
作者信息
Yang Qiu E, Walsh Timothy Rutland, Liu Bao Tao, Zou Meng Ting, Deng Hui, Fang Liang Xing, Liao Xiao Ping, Sun Jian, Liu Ya Hong
机构信息
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
Department of Medical Microbiology, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4336-8. doi: 10.1128/AAC.00475-16. Print 2016 Jul.
We sequenced a novel conjugative multidrug resistance IncF plasmid, p42-2, isolated from Escherichia coli strain 42-2, previously identified in China. p42-2 is 106,886 bp long, composed of a typical IncFII-type backbone (∼54 kb) and one distinct acquired DNA region spanning ∼53 kb, harboring 12 antibiotic resistance genes [blaCTX-M-55, oqxA, oqxB, fosA3, floR, tetA(A), tetA(R), strA, strB, sul2, aph(3')-II, and ΔblaTEM-1]. The spread of these multidrug resistance determinants on the same plasmid is of great concern and, because of coresistance to antibiotics from different classes, is therapeutically challenging.
我们对一个新的接合型多药耐药IncF质粒p42-2进行了测序，该质粒从中国先前鉴定出的大肠杆菌菌株42-2中分离得到。p42-2长度为106,886 bp，由一个典型的IncFII型主干（约54 kb）和一个跨越约53 kb的独特获得性DNA区域组成，该区域含有12个抗生素抗性基因[blaCTX-M-55、oqxA、oqxB、fosA3、floR、tetA(A)、tetA(R)、strA、strB、sul2、aph(3')-II和ΔblaTEM-1]。这些多药耐药决定簇在同一质粒上的传播令人高度关注，并且由于对不同类别的抗生素存在共同耐药性，在治疗上具有挑战性。
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