β-连环蛋白在口腔癌中差异表达的意义
Implications of Differential Expression of β-Catenin in Oral Carcinoma.
作者信息
Moles Miguel Angel Gonzalez, Montoya José Antonio Gil, Salvago Maria Dolores Martín, Ávila Isabel Ruiz, Campillo Juan José Plaza, Bravo Manuel
机构信息
School of Dentistry, Granada Biomedicine Institute, University of Granada, Granada, Spain
School of Dentistry, Granada Biomedicine Institute, University of Granada, Granada, Spain.
出版信息
Anticancer Res. 2016 Apr;36(4):1599-604.
BACKGROUND
Alterations of β-catenin can promote cancer progression, but there has been little analysis of this protein in oral squamous cell carcinoma (OSCC). The objective of this study was to investigate the role of β-catenin in OSCC development.
MATERIALS AND METHODS
Expression of β-catenin and Ki-67 from 92 OSCC was immunohistochemically studied in tissues close to the tumor invasion point and, in 37 cases, in tissues distant from the invasion point.
RESULTS
Loss of membranous β-catenin expression was observed in 77.2% of "close" samples and 94.4% of "distant" samples. Nuclear β-catenin expression was detected in 35.9% of adjacent samples and 44.4% of "distant" samples. Nuclear β-catenin expression in ≥10% of cells was observed in 6.6% of "close" samples and 25% of "distant" samples. No relationship was found between β-catenin expression and cell proliferation.
CONCLUSION
β-Catenin plays a major oncogenic role in OSCC, principally through increase in invasiveness due to loss of its membranous expression.
背景
β-连环蛋白的改变可促进癌症进展，但在口腔鳞状细胞癌（OSCC）中对该蛋白的分析较少。本研究的目的是探讨β-连环蛋白在OSCC发生发展中的作用。
材料与方法
采用免疫组织化学方法研究了92例OSCC肿瘤浸润点附近组织中β-连环蛋白和Ki-67的表达情况，并对其中37例远离浸润点的组织进行了研究。
结果
在77.2%的“近”端样本和94.4%的“远”端样本中观察到膜性β-连环蛋白表达缺失。在35.9%的相邻样本和44.4%的“远”端样本中检测到核β-连环蛋白表达。在6.6%的“近”端样本和25%的“远”端样本中观察到≥10%的细胞有核β-连环蛋白表达。未发现β-连环蛋白表达与细胞增殖之间存在关联。
结论
β-连环蛋白在OSCC中起主要致癌作用，主要是通过其膜性表达缺失导致侵袭性增加。
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