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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Comp Biochem Physiol B. 1989;92(1):151-6. doi: 10.1016/0305-0491(89)90328-3.

Red cell pyruvate kinase (EC 2.7.1.40) and hexokinase (EC 2.7.1.1) in high and low potassium (K) dogs were shown to exist as multiple forms which were separable by electrophoresis and ion-exchange chromatography. The R2-type pyruvate kinase, which was determined to be a young type enzyme in canine red cells, was shown to be the predominant form of pyruvate kinase in high K cells. 2. The M2-type pyruvate kinase, a prototype isozyme in erythroid cells, existed in high K dog erythrocytes as well as in high K and low K dog reticulocytes. 3. Isozyme analysis of high K red cell hexokinase also showed a profile similar to that obtained for low K reticulocytes. 4. These results seem to reflect the immaturity of high K erythrocytes, which suggest that an abnormal cell differentiation or maturation may occur at an early stage of erythroid cell proliferation in high K dogs.

高钾和低钾犬红细胞中的丙酮酸激酶（EC 2.7.1.40）和己糖激酶（EC 2.7.1.1）表现为多种形式，可通过电泳和离子交换色谱分离。R2型丙酮酸激酶被确定为犬红细胞中的一种年轻型酶，它是高钾细胞中丙酮酸激酶的主要形式。2. M2型丙酮酸激酶是红细胞系细胞中的一种原型同工酶，存在于高钾犬红细胞以及高钾和低钾犬网织红细胞中。3. 高钾红细胞己糖激酶的同工酶分析也显示出与低钾网织红细胞相似的图谱。4. 这些结果似乎反映了高钾红细胞的不成熟，这表明在高钾犬红细胞系细胞增殖的早期阶段可能发生异常的细胞分化或成熟。

Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Comp Biochem Physiol B. 1989;92(1):151-6. doi: 10.1016/0305-0491(89)90328-3.

Red cell pyruvate kinase (EC 2.7.1.40) and hexokinase (EC 2.7.1.1) in high and low potassium (K) dogs were shown to exist as multiple forms which were separable by electrophoresis and ion-exchange chromatography. The R2-type pyruvate kinase, which was determined to be a young type enzyme in canine red cells, was shown to be the predominant form of pyruvate kinase in high K cells. 2. The M2-type pyruvate kinase, a prototype isozyme in erythroid cells, existed in high K dog erythrocytes as well as in high K and low K dog reticulocytes. 3. Isozyme analysis of high K red cell hexokinase also showed a profile similar to that obtained for low K reticulocytes. 4. These results seem to reflect the immaturity of high K erythrocytes, which suggest that an abnormal cell differentiation or maturation may occur at an early stage of erythroid cell proliferation in high K dogs.

高钾和低钾犬红细胞中的丙酮酸激酶（EC 2.7.1.40）和己糖激酶（EC 2.7.1.1）表现为多种形式，可通过电泳和离子交换色谱分离。R2型丙酮酸激酶被确定为犬红细胞中的一种年轻型酶，它是高钾细胞中丙酮酸激酶的主要形式。2. M2型丙酮酸激酶是红细胞系细胞中的一种原型同工酶，存在于高钾犬红细胞以及高钾和低钾犬网织红细胞中。3. 高钾红细胞己糖激酶的同工酶分析也显示出与低钾网织红细胞相似的图谱。4. 这些结果似乎反映了高钾红细胞的不成熟，这表明在高钾犬红细胞系细胞增殖的早期阶段可能发生异常的细胞分化或成熟。