Plasma catecholamines were determined in turkey embryos. 2. Decreased eggshell permeability depressed dopamine and epinephrine, but increased permeability also depressed epinephrine. 3. Norepinephrine (NE) was greatest before transition to convective respiration when hypoxia occurs. 4. NE was associated inversely with eggshell permeability. 5. Catecholamines appear to assist the embryo during hatching hypoxia.