Momtaz Hossein-Emad, Dehghan Arash, Karimian Mohammad
Division of pediatric nephrology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pathology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
J Renal Inj Prev. 2016 Feb 24;5(1):25-8. doi: 10.15171/jrip.2016.06. eCollection 2016.
The use of a simple and accurate glomerular filtration rate (GFR) estimating method aiming minute assessment of renal function can be of great clinical importance.
This study aimed to determine the association of a GFR estimating by equation that includes only cystatin C (Gentian equation) to equation that include only creatinine (Schwartz equation) among children.
A total of 31 children aged from 1 day to 5 years with the final diagnosis of unilateral or bilateral hydronephrosis referred to Besat hospital in Hamadan, between March 2010 and February 2011 were consecutively enrolled. Schwartz and Gentian equations were employed to determine GFR based on plasma creatinine and cystatin C levels, respectively.
The proportion of GFR based on Schwartz equation was 70.19± 24.86 ml/min/1.73 m(2), while the level of this parameter based on Gentian method and using cystatin C was 86.97 ± 21.57 ml/min/1.73 m(2). The Pearson correlation coefficient analysis showed a strong direct association between the two levels of GFR measured by Schwartz equation based on serum creatinine level and Gentian method and using cystatin C (r = 0.594, P < 0.001). The linear association between GFR values measured with the two methods included cystatin C based GFR = 50.8+ 0.515 × Schwartz GFR. The correlation between GFR values measured by using serum creatinine and serum cystatin C measurements remained meaningful even after adjustment for patients' gender and age (r = 0.724, P < 0.001).
The equation developed based on cystatin C level is comparable with another equation, based on serum creatinine (Schwartz formula) to estimate GFR in children.
采用一种简单准确的肾小球滤过率（GFR）估算方法以实现对肾功能的精细评估具有重大临床意义。
本研究旨在确定儿童中仅包含胱抑素C的估算GFR的方程（龙胆方程）与仅包含肌酐的方程（施瓦茨方程）之间的关联。
2010年3月至2011年2月期间，连续纳入了共31名年龄从1天至5岁、最终诊断为单侧或双侧肾积水的儿童，这些儿童均转诊至哈马丹的贝萨特医院。分别采用施瓦茨方程和龙胆方程，根据血浆肌酐和胱抑素C水平来确定GFR。
基于施瓦茨方程的GFR比例为70.19±24.86毫升/分钟/1.73平方米，而基于龙胆方法并使用胱抑素C的该参数水平为86.97±21.57毫升/分钟/1.73平方米。皮尔逊相关系数分析显示，基于血清肌酐水平的施瓦茨方程所测GFR水平与基于胱抑素C的龙胆方法所测GFR水平之间存在强正相关（r = 0.594，P < 0.001）。两种方法所测GFR值之间的线性关联为基于胱抑素C的GFR = 50.8 + 0.515×施瓦茨GFR。即使在对患者的性别和年龄进行校正后，使用血清肌酐和血清胱抑素C测量所测GFR值之间的相关性仍然显著（r = 0.724，P < 0.001）。
基于胱抑素C水平制定的方程与基于血清肌酐的另一个方程（施瓦茨公式）在估算儿童GFR方面具有可比性。
