Godoy R F, Coathup M J, Blunn G W, Alves A L, Robotti P, Goodship A E
Institute of Orthopaedics and Musculoskeletal Science, Brockley Hill, HA7 4LP, Middlesex,
Eur Cell Mater. 2016 Apr 13;31:250-63. doi: 10.22203/ecm.v031a17.
We explored the osseointegration potential of two macroporous titanium surfaces obtained using fast plasma sintering (FPS): Ti macroporous structures with 400-600 µmØ pores (TiMac400) and 850-1000 µmØ pores (TiMac850). They were compared against two surfaces currently in clinical use: Ti-Growth® and air plasma spray (Ti-Y367). Each surface was tested, once placed over a Ti-alloy and once onto a CoCr bulk substrate. Implants were placed in medial femoral condyles in 24 sheep. Samples were explanted at four and eight weeks after surgery. Push-out loads were measured using a material-testing system. Bone contact and ingrowth were assessed by histomorphometry and SEM and EDX analyses. Histology showed early osseointegration for all the surfaces tested. At 8 weeks, TiMac400, TiMac850 and Ti-Growth® showed deep bone ingrowth and extended colonisation with newly formed bone. The mechanical push-out force was equal in all tested surfaces. Plasma spray surfaces showed greater bone-implant contact and higher level of pores colonisation with new bone than FPS produced surfaces. However, the void pore area in FPS specimens was significantly higher, yet the FPS porous surfaces allowed a deeper osseointegration of bone to implant. FPS manufactured specimens showed similar osseointegration potential to the plasma spray surfaces for orthopaedic implants. FPS is a useful technology for manufacturing macroporous titanium surfaces. Furthermore, its capability to combine two implantable materials, using bulk CoCr with macroporous titanium surfaces, could be of interest as it enables designers to conceive and manufacture innovative components. FPS delivers functional graded materials components with macroporous structures optimised for osseointegration.
我们探究了通过快速等离子烧结（FPS）获得的两种大孔钛表面的骨整合潜力：孔径为400 - 600 µm的Ti大孔结构（TiMac400）和孔径为850 - 1000 µm的Ti大孔结构（TiMac850）。将它们与目前临床使用的两种表面进行比较：Ti - Growth®和空气等离子喷涂表面（Ti - Y367）。每个表面都进行了测试，一次放置在钛合金上，一次放置在钴铬合金块体基材上。将植入物植入24只绵羊的股骨内侧髁。术后四周和八周取出样本。使用材料测试系统测量推出载荷。通过组织形态计量学、扫描电子显微镜（SEM）和能谱分析（EDX）评估骨接触和骨长入情况。组织学显示所有测试表面均有早期骨整合。在8周时，TiMac400、TiMac850和Ti - Growth®显示出深部骨长入以及新形成骨的广泛定植。所有测试表面的机械推出力相等。与快速等离子烧结生产的表面相比，等离子喷涂表面显示出更大的骨 - 植入物接触以及新骨对孔隙的更高定植水平。然而，快速等离子烧结样本中的孔隙空洞面积显著更高，但快速等离子烧结的多孔表面允许骨与植入物实现更深的骨整合。对于骨科植入物，快速等离子烧结制造的样本显示出与等离子喷涂表面相似的骨整合潜力。快速等离子烧结是制造大孔钛表面的一项有用技术。此外，它能够将两种可植入材料结合起来，即使用钴铬合金块体与大孔钛表面，这可能会引起人们的兴趣，因为它使设计者能够构思和制造创新部件。快速等离子烧结可提供具有为骨整合优化的大孔结构的功能梯度材料部件。
