心血管系统中的硫化氢：硫原子与信号分子相互作用引发的级联反应
Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules.
作者信息
Wang Ming-Jie, Cai Wen-Jie, Zhu Yi-Chun
机构信息
Research Center on Aging and Medicine, Fudan University, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Basic Medicine, College of Medical Instruments and Foodstuff, University of Shanghai for Science and Technology, Shanghai, China.
出版信息
Life Sci. 2016 May 15;153:188-97. doi: 10.1016/j.lfs.2016.03.057. Epub 2016 Apr 9.
As a gasotransmitter, hydrogen sulphide exerts its extensive physiological and pathophysiological effects in mammals. The interaction between sulphur atoms and signalling molecules forms a cascade that modulates cellular functions and homeostasis. In this review, we focus on the signalling mechanism underlying the effect of hydrogen sulphide in the cardiovascular system and metabolism as well as the biological relevance to human diseases.
作为一种气体信号分子，硫化氢在哺乳动物体内发挥着广泛的生理和病理生理作用。硫原子与信号分子之间的相互作用形成了一个调节细胞功能和内稳态的级联反应。在本综述中，我们重点关注硫化氢在心血管系统和代谢中的作用机制以及与人类疾病的生物学关联。
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